Autor según el artículo: Auguet, Teresa; Bertran, Laia; Binetti, Jessica; Aguilar, Carmen; Martinez, Salome; Guiu-Jurado, Esther; Sabench, Fatima; Adalid, Laia; Antonio Porras, Jose; Riesco, David; Del Castillo, Daniel; Richart, Cristobal
Departamento: Medicina i Cirurgia
Autor/es de la URV: Adalid Llansà, Laia / Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Binetti, Jessica Angela / Del Castillo Déjardin, Daniel / GUIU JURADO, ESTHER / Martínez González, María Salomé / Porras Ledantes, Jose Antonio / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima
Palabras clave: Signal transduction Receptors, notch Obesity Non-alcoholic fatty liver disease Middle aged Lipid metabolism Insulin-resistance Inhibition Humans Hepatocytes Fibrosis Female Differentiation Cohort studies Animals Adaptive immunity
Resumen: Objective This cohort study aimed to explore the relationship between the Notch signaling pathway and the degree of nonalcoholic fatty liver disease (NAFLD). Moreover, this study intended to investigate whether this pathway is related to hepatic lipid metabolism and Toll-like receptors (TLRs). Methods This study used real-time polymerase chain reaction analysis to evaluate the hepatic expression level of all genes studied (Notch receptorsNOTCH1,NOTCH2,NOTCH3, andNOTCH4, transcription factorsHES1andHES5, and Hes-related repressor proteinsHEY1andHEY2) in hepatic tissue from two cohorts: women with severe obesity (n = 57) and normal liver structure (n = 20) or NAFLD (n = 37). Results In women with severe obesity and NAFLD, this study found downregulation of hepaticHES5expression. This expression correlated positively with the hepatic expression ofHES1,HEY1, andNOTCH3. This study also found a positive correlation betweenHES5expression and sterol regulatory element-binding protein 1c (SREBP1c) and betweenNOTCH3and several genes related to hepatic lipid metabolism (encoding liver X nuclear receptor alpha variant 1, farnesoid X nuclear receptor,SREBP1c, acetyl-CoA carboxylase 1, fatty acid synthase, peroxisome proliferator-activated receptor alpha, carnitine palmitoyltransferase 1, carnitineO-octanoyltransferase, ATP-binding cassette subfamily A member 1, and ATP-binding cassette subfamily G member 1). Finally, this study found a positive correlation betweenNOTCH2andTLR2,TLR4, andTLR9and a positive relationship betweenNOTCH1andTLR9. Conclusions Taken together, these findings suggest that hepatic expression of Notch proteins and ligands in relation to lipid metabolism pathways in the liver could have a role in NAFLD pathogenesis.
Áreas temáticas: Saúde coletiva Psicología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: joseantonio.porras@urv.cat mariasalome.martinez@urv.cat danieldel.castillo@urv.cat jessicaangela.binetti@estudiants.urv.cat laia.adalid@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Identificador del autor: 0000-0001-6418-1822 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9660-7752 0000-0001-7543-9921 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/oby.22873
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Obesity. 28 (8): 1487-1493
Referencia de l'ítem segons les normes APA: Auguet, Teresa; Bertran, Laia; Binetti, Jessica; Aguilar, Carmen; Martinez, Salome; Guiu-Jurado, Esther; Sabench, Fatima; Adalid, Laia; Antonio Porras (2020). Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver. Obesity, 28(8), 1487-1493. DOI: 10.1002/oby.22873
DOI del artículo: 10.1002/oby.22873
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications