Autor según el artículo: David Parada D; Peña G KB; Vives M; Molina A; Mayayo E; Riu F; Sabench F; del Castillo D

Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques

Autor/es de la URV: Del Castillo Déjardin, Daniel / Mayayo Artal, Emilio Manuel / MOLINA LÓPEZ, ALICIA / Sabench Pereferrer, Fàtima

Palabras clave: Serum Rats Obesity Laparoscopic surgery Laparoscopic sleeve gastrectomy Identification Hormone Histopathology Helicobacter-pylori infection Ghrelin Gastric Endocrine Cells Acylated peptide laparoscopic surgery ghrelin gastric cells

Resumen: © 2020 Parada D et al. Purpose: The cellular distribution of ghrelin positive cells is not well defined. The aim of the study is to quantify and determine the distribution of ghrelin cells in gastric mucosa in patients with morbid obesity and relate this finding to gender, comorbidities, gastritis, and plasmatic levels of acyl and desacylghrelin before and after laparoscopic sleeve gastrectomy. Patient and Methods: We performed a study on 61 patients with BMI≥50 kg/m2 operated by laparoscopic sleeve gastrectomy. Three gastric regions were analyzed by histopathology and immunohistology. Blood sample was taken before surgery, and at 6 and 12 months post-surgery, to study the plasma levels of ghrelin isoforms. Results: Ghrelin cells are present in all regions of the gastric mucosa, with a greater number in the body and the fundus. Difference was found in the antrum between male and female patients (p=0.018). Patients with arterial hypertension also showed a lower level of cells in antrum (p<0.05). Acylghrelin levels after surgery were significantly lower (32.83+5.6 pg/mL to 10.09+11.8 pg/mL, p<0.05). Values of desacylghrelin tended to decrease but no significant variation was observed (207.4+39.3 pg/mL to 188.84+52.3 pg/mL). Conclusion: Our patients show ghrelin cells in all areas of the stomach. Gender, comorbid-ities, and gastritis are determinant on gastric ghrelin-producing cells distribution.

Áreas temáticas: Saúde coletiva Pharmacology Odontología Nutrição Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 11787007

Direcció de correo del autor: danieldel.castillo@urv.cat emilio.mayayo@urv.cat fatima.sabench@urv.cat

Identificador del autor: 0000-0003-0456-3102 0000-0001-7024-7824 0000-0003-4485-3809 0000-0002-9262-8756

Fecha de alta del registro: 2023-02-23

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443401/

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Diabetes Metabolic Syndrome And Obesity-Targets And Therapy. 13 2855-2864

Referencia de l'ítem segons les normes APA: David Parada D; Peña G KB; Vives M; Molina A; Mayayo E; Riu F; Sabench F; del Castillo D (2020). Quantitative and topographic analysis by immunohistochemical expression of ghrelin gastric cells in patients with morbid obesity. Diabetes Metabolic Syndrome And Obesity-Targets And Therapy, 13(), 2855-2864. DOI: 10.2147/DMSO.S260483

DOI del artículo: 10.2147/DMSO.S260483

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications