Articles producció científica> Bioquímica i Biotecnologia

Involvement of JNK1 in Neuronal Polarization During Brain Development

  • Datos identificativos

    Identificador: imarina:8679850
    Autores:
    Castro-Torres, Ruben DarioBusquets, OriolParcerisas, AntoniVerdaguer, EsterOlloquequi, JordiEtchetto, MirenBeas-Zarate, CarlosFolch, JaumeCamins, AntoniAuladell, Carme
    Resumen:
    The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell division of neural stem cells and ending with their final positioning when migrating and maturing. This review will focus mostly on isoform JNK1, the foremost contributor of total JNK activity in the CNS. Throughout the text, research from multiple groups will be summarized and discussed in order to describe the involvement of the JNKs in the different steps of neuronal polarization. The data presented support the idea that isoform JNK1 is highly relevant to the regulation of many of the processes that occur in neuronal development in the CNS.
  • Otros:

    Autor según el artículo: Castro-Torres, Ruben Dario; Busquets, Oriol; Parcerisas, Antoni; Verdaguer, Ester; Olloquequi, Jordi; Etchetto, Miren; Beas-Zarate, Carlos; Folch, Jaume; Camins, Antoni; Auladell, Carme;
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Folch Lopez, Jaume
    Palabras clave: Wdr62 Synaptogenesis Synaptic function Signaling pathway Scg10 Scaffold proteins Phosphorylation Nmdar N-terminal kinase Migration Map1b Jnk1 Induced neurite outgrowth Distinct roles Dcx Axon elongation Asymmetric division Activation wdr62 scg10 nmdar migration map1b jnk1 dcx asymmetric division
    Resumen: The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell division of neural stem cells and ending with their final positioning when migrating and maturing. This review will focus mostly on isoform JNK1, the foremost contributor of total JNK activity in the CNS. Throughout the text, research from multiple groups will be summarized and discussed in order to describe the involvement of the JNKs in the different steps of neuronal polarization. The data presented support the idea that isoform JNK1 is highly relevant to the regulation of many of the processes that occur in neuronal development in the CNS.
    Áreas temáticas: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20734409
    Direcció de correo del autor: jaume.folch@urv.cat
    Identificador del autor: 0000-0002-5051-8858
    Fecha de alta del registro: 2023-04-15
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2073-4409/9/8/1897
    Referencia al articulo segun fuente origial: Cells. 9 (8):
    Referencia de l'ítem segons les normes APA: Castro-Torres, Ruben Dario; Busquets, Oriol; Parcerisas, Antoni; Verdaguer, Ester; Olloquequi, Jordi; Etchetto, Miren; Beas-Zarate, Carlos; Folch, Jau (2020). Involvement of JNK1 in Neuronal Polarization During Brain Development. Cells, 9(8), -. DOI: 10.3390/cells9081897
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3390/cells9081897
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Cell Biology,Medicine (Miscellaneous)
    Wdr62
    Synaptogenesis
    Synaptic function
    Signaling pathway
    Scg10
    Scaffold proteins
    Phosphorylation
    Nmdar
    N-terminal kinase
    Migration
    Map1b
    Jnk1
    Induced neurite outgrowth
    Distinct roles
    Dcx
    Axon elongation
    Asymmetric division
    Activation
    wdr62
    scg10
    nmdar
    migration
    map1b
    jnk1
    dcx
    asymmetric division
    Medicine (miscellaneous)
    Cell biology
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
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