Autor según el artículo: Parada D D; Peña KB; Gumá J; Guilarte C; Riu F
Departamento: Medicina i Cirurgia
Autor/es de la URV: Gumà Padró, José / Parada Dominguez, David
Palabras clave: Viral transport medium Swab Sars‐ Sars-cov-2 Rt‐ Rt-pcr Receptor Pcr Nasopharynx Liquid‐ Liquid-based Immunohistochemical Cytology Cov‐ Covid‐ Covid-19 Based 2 19
Resumen: Introduction We describe cytologic and immunohistologic findings in virus transport medium on cases under investigation of SARS-CoV-2 infection.
Methods Cytologic findings in cases under investigation of SARS-CoV-2 infection from one hundred consecutive nasopharyngeal swab were reviewed. Immunohistochemistry and SARSCoV-2 RT-PCR determination were performed to detect virus.
Results No viral inclusions were noted in squamous cells obtained from virus transport medium. Immunohistochemical study with monoclonal antibody against SARS-CoV-2 viral nucleoprotein showed positivity in squamous cells. No positivity was present in others cellular components.
Conclusions SARS-CoV-2 predominantly localizes squamous cells in cytology samples of patients with RT-PCR positive determination of SARSCoV-2. The results of the current study support the notion that the nasopharyngeal region is the anatomical station that SARS-CoV-2 infects first, and the infection can lead to the migration of the virus into the lower airways.
Áreas temáticas: Pathology and forensic medicine Pathology Odontología Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar Histology General medicine Engenharias iv Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cell biology Biotecnología Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: david.parada@urv.cat jose.guma@urv.cat
Identificador del autor: 0000-0001-7541-9832
Fecha de alta del registro: 2024-01-13
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1111/his.14257
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Histopathology. 78 (4): 586-592
Referencia de l'ítem segons les normes APA: Parada D D; Peña KB; Gumá J; Guilarte C; Riu F (2021). Liquid-based cytological and immunohistochemical study of nasopharyngeal swab from persons under investigation for SARS-CoV-2 infection. Histopathology, 78(4), 586-592. DOI: 10.1111/his.14257
DOI del artículo: 10.1111/his.14257
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV