Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Magnetic nanoparticle decorated anodic alumina nanotubes for fluorescent detection of cathepsin B

  • Datos identificativos

    Identificador: imarina:9002284
    Autores:
    Domagalski, J TXifre-Perez, ETabrizi, M AFerre-Borrull, JMarsal, L F
    Resumen:
    © 2020 Elsevier Inc. In this work, we present the process to provide anodic alumina nanotubes with magnetic responsivity based on magnetic nanoparticles. We demonstrate the possibility to cause the motion of these composite nanotubes under magnetic field, providing them with guided mobility. The obtained magnetic anodic alumina nanotubes are completely characterized and their potential to undergo selective and effective functionalization, and stimuli-responsive load release is demonstrated. For this purpose, protease-triggered release of fluorescent molecules loaded inside the magnetic anodic alumina nanotubes (MAANTs) by selective functionalization is performed. The inner walls of the MAANTs were selectively covered with protein padding of albumin-fluorescein isothiocyanate conjugate (FITC-BSA) through means of silanization. Protein functionalization was designed to undergo proteolytic hydrolysis in presence of cathepsin B- protease highly expressed during growth and initial stages of tumor metastasis – in order to cleave peptide bond of albumin and release fluorescent fragments of the protein. Proteolytic reaction with the enzyme is performed under acidic conditions. Presented arrangement is an exemplary combination of functionalities – which are vast – and of value for applications like drug delivery and biosensing applications.
  • Otros:

    Autor según el artículo: Domagalski, J T; Xifre-Perez, E; Tabrizi, M A; Ferre-Borrull, J; Marsal, L F
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: DOMAGALSKI, JAKUB / Ferré Borrull, José / Marsal Garví, Luis Francisco / Xifré Pérez, Elisabet
    Código de proyecto: Grant agreement No. 713679
    Palabras clave: Stimuli-responsive release Self-assembly Magnetic properties Cathepsin b Anodic alumina nanotubes
    Resumen: © 2020 Elsevier Inc. In this work, we present the process to provide anodic alumina nanotubes with magnetic responsivity based on magnetic nanoparticles. We demonstrate the possibility to cause the motion of these composite nanotubes under magnetic field, providing them with guided mobility. The obtained magnetic anodic alumina nanotubes are completely characterized and their potential to undergo selective and effective functionalization, and stimuli-responsive load release is demonstrated. For this purpose, protease-triggered release of fluorescent molecules loaded inside the magnetic anodic alumina nanotubes (MAANTs) by selective functionalization is performed. The inner walls of the MAANTs were selectively covered with protein padding of albumin-fluorescein isothiocyanate conjugate (FITC-BSA) through means of silanization. Protein functionalization was designed to undergo proteolytic hydrolysis in presence of cathepsin B- protease highly expressed during growth and initial stages of tumor metastasis – in order to cleave peptide bond of albumin and release fluorescent fragments of the protein. Proteolytic reaction with the enzyme is performed under acidic conditions. Presented arrangement is an exemplary combination of functionalities – which are vast – and of value for applications like drug delivery and biosensing applications.
    Áreas temáticas: Surfaces, coatings and films Química Nutrição Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Electronic, optical and magnetic materials Economia Colloid and surface chemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, physical Biotecnología Biomaterials Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: josep.ferre@urv.cat elisabet.xifre@urv.cat lluis.marsal@urv.cat
    Identificador del autor: 0000-0002-5210-5133 0000-0001-6072-9889 0000-0002-5976-1408
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0021979720312984?via%3Dihub
    Programa de financiación: Marti i Franquès COFUND Doctoral Programme
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of Colloid And Interface Science. 584 236-245
    Referencia de l'ítem segons les normes APA: Domagalski, J T; Xifre-Perez, E; Tabrizi, M A; Ferre-Borrull, J; Marsal, L F (2021). Magnetic nanoparticle decorated anodic alumina nanotubes for fluorescent detection of cathepsin B. Journal Of Colloid And Interface Science, 584(), 236-245. DOI: 10.1016/j.jcis.2020.09.109
    Acrónimo: MFP
    DOI del artículo: 10.1016/j.jcis.2020.09.109
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Acción del progama de financiación: Marie Skłodowska-Curie Actions - European Union's Horizon 2020 research and innovation programme
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biomaterials,Chemistry, Physical,Colloid and Surface Chemistry,Electronic, Optical and Magnetic Materials,Surfaces, Coatings and Films
    Stimuli-responsive release
    Self-assembly
    Magnetic properties
    Cathepsin b
    Anodic alumina nanotubes
    Surfaces, coatings and films
    Química
    Nutrição
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Electronic, optical and magnetic materials
    Economia
    Colloid and surface chemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, physical
    Biotecnología
    Biomaterials
    Biodiversidade
    Astronomia / física
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