Autor según el artículo: Diaz-Lopez, Andres; Iglesias-Vazquez, Lucia; Palleja-Millan, Meritxell; Rey Renones, Cristina; Flores Mateo, Gemma; Arija, Victoria;

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Arija Val, Maria Victoria / Díaz López, Andres / Iglesias Vazquez, Lucia

Palabras clave: Type 2 diabetes incidence Type 2 diabetes Stores Serum ferritin levels Serum ferritin Primary healthcare Plasma ferritin Metaanalysis Mellitus Iron status Insulin-resistance Health Body iron Biomarkers Atherosclerosis risk

Resumen: Type 2 diabetes poses a major public health challenge. Here, we conducted a cohort study with a large sample size to determine the association of baseline serum ferritin (SF), a marker of iron status, with incident type 2 diabetes in primary healthcare patients in Catalonia, a western Mediterranean region. A total of 206,115 patients aged 35-75 years without diabetes and with available baseline SF measurements were eligible. The variables analyzed included sociodemographic characteristics, anthropometry, lifestyle, morbidity and iron status (SF, serum iron and hemoglobin). Incident type 2 diabetes during follow-up (2006-2016) was ascertained using the International Classification of Diseases, 10th edition. Cox proportional-hazards models adjusted for multiple baseline confounders/mediators were used to estimate hazard ratios (HRs). Over a median follow-up of 8.4 years, 12,371 new cases of type 2 diabetes were diagnosed, representing an incidence rate of 7.5 cases/1000 persons/year. Since at baseline, the median SF concentration was higher in subjects who developed type 2 diabetes (107.0 mu g/L vs. 60.3 mu g/L; p < 0.001), SF was considered an independent risk predictor for type 2 diabetes; the multivariable-adjusted HRs for incident type 2 diabetes across SF quartiles 1-4 were 1.00 (reference), 0.95 (95% CI = 0.85-1.06), 1.18 (95% CI = 1.65-1.31) and 1.51 (95% CI = 1.36-1.65), respectively. Our study suggested that higher baseline SF was significantly associated with an increased risk of new-onset type 2 diabetes in Catalan primary healthcare users, supporting the relevance of monitoring iron stores in order to improve the diagnosis and management of diabetes in clinical practice.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: lucia.iglesias@urv.cat andres.diaz@urv.cat victoria.arija@urv.cat lucia.iglesias@urv.cat

Identificador del autor: 0000-0001-7131-4144 0000-0002-7500-5629 0000-0002-1758-0975 0000-0001-7131-4144

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6643/12/11/3249

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 12 (11):

Referencia de l'ítem segons les normes APA: Diaz-Lopez, Andres; Iglesias-Vazquez, Lucia; Palleja-Millan, Meritxell; Rey Renones, Cristina; Flores Mateo, Gemma; Arija, Victoria; (2020). Association between Iron Status and Incident Type 2 Diabetes: A Population-Based Cohort Study. Nutrients, 12(11), -. DOI: 10.3390/nu12113249

DOI del artículo: 10.3390/nu12113249

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications