Autor según el artículo: Boughanem H; Hernandez-Alonso P; Tinahones A; Babio N; Salas-Salvadó J; Tinahones FJ; Macias-Gonzalez M

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge

Palabras clave: Vitamin b12 Line1 Dna methylation Colorectal cancer

Resumen: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Vitamin B12 has been widely related to methionine metabolism, which is an essential component for biological methylation reactions, including DNA methylation. However, the relationship between vitamin B12 and DNA methylation is still controversial. In addition, there is increasing evidence for the association between vitamin B12 and the risk of colorectal cancer (CRC), although results of this association need to be assessed with caution. For this purpose, we hypothesized that serum vitamin B12 could be associated with global DNA methylation in the CRC context. To test this hypothesis, we studied the association between global DNA methylation through long interspersed nuclear element-1 (LINE1) in CRC patients under the 25th percentile of serum vitamin B12. We found that the high vitamin B12 group had low LINE1 methylation in both tumor area and peripheral blood mononuclear cells (PBMCs) than the low serum vitamin B12 group. LINE1 methylation levels were significantly lower in tumor area compared to the adjacent tumor-free area, only in the high vitamin B12 group. LINE1 methylation in visceral adipose tissue (VAT) and PBMCs were correlated with tumoral, inflammatory, and insulin metabolism markers. However, the interaction between LINE1 methylation and vitamin B12 levels was associated with neoadjuvant therapy in the regression analysis only in men, suggesting a beneficial relationship. In conclusion, our results reported an inverse association between DNA methylation and vitamin B12 in the CRC context, which suggests that vitamin B12 may be implicated in an epigenetic state or mediation in CRC.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: nancy.babio@urv.cat jordi.salas@urv.cat

Identificador del autor: 0000-0003-3527-5277 0000-0003-2700-7459

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6643/12/11/3567

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 12 (11): 1-12

Referencia de l'ítem segons les normes APA: Boughanem H; Hernandez-Alonso P; Tinahones A; Babio N; Salas-Salvadó J; Tinahones FJ; Macias-Gonzalez M (2020). Association between serum vitamin B12 and global dna methylation in colorectal cancer patients. Nutrients, 12(11), 1-12. DOI: 10.3390/nu12113567

DOI del artículo: 10.3390/nu12113567

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications