Autor según el artículo: Miguéns-Gómez A; Casanova-Martí À; Blay MT; Terra X; Beltrán-Debón R; Rodríguez-Gallego E; Ardévol A; Pinent M

Departamento: Bioquímica i Biotecnologia Medicina i Cirurgia

Autor/es de la URV: Ardèvol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / CASANOVA MARTÍ, ANGELA / Pinent Armengol, Montserrat / Terra Barbadora, Ximena

Palabras clave: Secretagogue Iv inhibitory-activity Hydrolysate Glp-1 Enterohormones Enterohormone Dietary protein zein hydrolysate whey-protein skin gelatin hydrolysate secretagogues improves glucose-tolerance hydrolysates glycemic control glucagon-like peptide-1 glp-1 secretion enteroendocrine cells dietary protein bioactive peptides angiotensin-converting enzyme

Resumen: © The Author(s) 2021. Glucagon-like peptide 1 (GLP-1) is an enterohormone with a key role in several processes controlling body homeostasis, including glucose homeostasis and food intake regulation. It is secreted by the intestinal cells in response to nutrients, such as glucose, fat and amino acids. In this review, we analyse the effect of protein on GLP-1 secretion and clearance. We review the literature on the GLP-1 secretory effects of protein and protein hydrolysates, and the mechanisms through which they exert these effects. We also review the studies on protein from different sources that has inhibitory effects on DPP4, the enzyme responsible for GLP-1 inactivation, with particular emphasis on specific sources and treatments, and the gaps there still are in knowledge. There is evidence that the protein source and the hydrolytic processing applied to them can influence the effects on GLP-1 signalling. The gastrointestinal digestion of proteins, for example, significantly changes their effectiveness at modulating this enterohormone secretion in both in vivo and in vitro studies. Nevertheless, little information is available regarding human studies and more research is required to understand their potential as regulators of glucose homeostasis.

Áreas temáticas: Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina ii Medicina i Educação física Ciências biológicas ii Ciências biológicas i

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: ximena.terra@urv.cat raul.beltran@urv.cat montserrat.pinent@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat

Identificador del autor: 0000-0003-1043-5844 0000-0001-9691-1906 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-0156-7538

Fecha de alta del registro: 2023-03-06

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.cambridge.org/core/journals/nutrition-research-reviews/article/abs/glucagonlike-peptide1-regulation-by-food-proteins-and-protein-hydrolysates/00330E164AA32CDB8B4877401F1B27CE#access-block

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrition Research Reviews. 34 (2): 1-48

Referencia de l'ítem segons les normes APA: Miguéns-Gómez A; Casanova-Martí À; Blay MT; Terra X; Beltrán-Debón R; Rodríguez-Gallego E; Ardévol A; Pinent M (2021). GLP-1 regulation by food proteins and protein hydrolysates. Nutrition Research Reviews, 34(2), 1-48. DOI: 10.1017/S0954422421000019

DOI del artículo: 10.1017/S0954422421000019

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications