Repositori URV

Autor según el artículo: Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, J Alfredo; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Lopez-Miranda, Jose; Cano Ibanez, Naomi; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Antonio de Paz, Jose; Vidal, Josep; Vazquez, Clotilde; Ruiz-Canela, Miguel; Bullo, Monica; Sorli, Jose, V; Goday, Albert; Fiol, Miquel; Garcia-de-la-Hera, Manoli; Sierra, Lucas Tojal; Perez-Farinos, Napoleon; Zulet, Maria Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Gimenez-Gracia, Miquel; Bibiloni, Maria Del Mar; Diez-Espino, Javier; Ortega-Azorin, Carolina; Castaner, Olga; Morey, Marga; Torres-Collado, Laura; Sorto Sanchez, Carolina; Angel Munoz, Miguel; Ros, Emilio; Martinez-Gonzalez, Miguel A; Salas-Salvado, Jordi

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Díaz López, Andres / Ruiz Garcia, Verónica / Salas Salvadó, Jorge

Palabras clave: Weight loss Waist circumference Systolic blood pressure Sensitivity analysis Randomized controlled trial Randomization Questionnaire Primary medical care Predimed-plus Physical activity Pathophysiology Outcome assessment Obesity Multicenter study Monte carlo method Monounsaturated fatty acid Middle aged Mediterranean diet Male Major clinical study Low density lipoprotein cholesterol Lifestyle Life style Kidney function tests Kidney function test Kidney function Kidney Incidence Humans Human experiment Human High density lipoprotein cholesterol Glycemic index Glucose metabolism Glucose blood level Glomerulus filtration rate Glomerular filtration rate Female Estimated glomerular filtration rate Energy expenditure Dyslipidemia Disease exacerbation Dipeptidyl carboxypeptidase Dietary intervention Diastolic blood pressure Diabetes mellitus Controlled study Comparative effectiveness Clinical trial Cardiovascular risk Cardiovascular disease Body weight loss Body mass Bariatric surgery Article Albumin to creatinine ratio Aged

Resumen: Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (<60 mL/min/1.73 m(2)) and micro- to macroalbuminuria (UACR >= 30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m(2)) to mildly impaired GFR (60 to <90 mL/min/1.73 m(2)) or micro- to macroalbuminuria. Results: After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m(2) in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m(2); 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. Conclusions: The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.

Áreas temáticas: Urology & nephrology Saúde coletiva Odontología Nutrição Nephrology Medicina ii Medicina i General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: veronica.ruiz@urv.cat andres.diaz@urv.cat nerea.becerra@urv.cat veronica.ruiz@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat

Identificador del autor: 0000-0002-7500-5629 0000-0002-4429-6507 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277

Fecha de alta del registro: 2024-10-12

Versión del articulo depositado: info:eu-repo/semantics/submittedVersion

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: American Journal Of Nephrology. 52 (1): 1-14

Referencia de l'ítem segons les normes APA: Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Je (2021). Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial. American Journal Of Nephrology, 52(1), 1-14. DOI: 10.1159/000513664

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications