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Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters

  • Datos identificativos

    Identificador: imarina:9187111
    Autores:
    Kapruwan, PankajAcosta, Laura KFerre-Borrull, JosepMarsal, Lluis F
    Resumen:
    In this work, a methodology that exploits the optical properties of the nanoporous anodic alumina gradient index filters (NAA-GIFs) has been developed and applied to evaluate in real time the release dynamics of a cargo molecule, acting as a model drug, filling the pores. NAA-GIFs with two photonic stopbands (PSBs) were prepared with one of its stop bands in the same absorption wavelength range of the cargo molecule, whereas the second stopband away from this absorption range. Numerical simulation and experiments confirm that the relative height of the high reflectance bands in the reflectance spectra of NAA-GIFs filled with the drug can be related to the relative amount of drug filling the pores. This property has been applied in a flow cell setup to measure in real-time the release dynamics of NAA-GIFs with the inner pore surface modified by layer-by-layer deposition of polyelectrolytes and loaded with the cargo molecule. The methodology developed in this work acts as a tool for the study of drug delivery from porous nanostructures.
  • Otros:

    Autor según el artículo: Kapruwan, Pankaj; Acosta, Laura K; Ferre-Borrull, Josep; Marsal, Lluis F
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: Acosta Capilla, Laura Karen / Ferré Borrull, José / Kapruwan, Pankaj / Marsal Garví, Luis Francisco
    Palabras clave: Rhodamine 6g Polyelectrolytes Photonic crystals Optical monitoring Nanoporous anodic alumina
    Resumen: In this work, a methodology that exploits the optical properties of the nanoporous anodic alumina gradient index filters (NAA-GIFs) has been developed and applied to evaluate in real time the release dynamics of a cargo molecule, acting as a model drug, filling the pores. NAA-GIFs with two photonic stopbands (PSBs) were prepared with one of its stop bands in the same absorption wavelength range of the cargo molecule, whereas the second stopband away from this absorption range. Numerical simulation and experiments confirm that the relative height of the high reflectance bands in the reflectance spectra of NAA-GIFs filled with the drug can be related to the relative amount of drug filling the pores. This property has been applied in a flow cell setup to measure in real-time the release dynamics of NAA-GIFs with the inner pore surface modified by layer-by-layer deposition of polyelectrolytes and loaded with the cargo molecule. The methodology developed in this work acts as a tool for the study of drug delivery from porous nanostructures.
    Áreas temáticas: Physics, applied Nanoscience & nanotechnology Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) General materials science General chemical engineering Engenharias ii Chemistry, multidisciplinary Chemical engineering (miscellaneous) Chemical engineering (all)
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: pankaj.kapruwan1@estudiants.urv.cat pankaj.kapruwan1@estudiants.urv.cat laurakaren.acosta@urv.cat josep.ferre@urv.cat lluis.marsal@urv.cat
    Identificador del autor: 0000-0002-5210-5133 0000-0002-5976-1408
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2079-4991/11/3/730
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nanomaterials. 11 (3): 1-16
    Referencia de l'ítem segons les normes APA: Kapruwan, Pankaj; Acosta, Laura K; Ferre-Borrull, Josep; Marsal, Lluis F (2021). Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters. Nanomaterials, 11(3), 1-16. DOI: 10.3390/nano11030730
    DOI del artículo: 10.3390/nano11030730
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemical Engineering (Miscellaneous),Chemistry, Multidisciplinary,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Nanoscience & Nanotechnology,Physics, Applied
    Rhodamine 6g
    Polyelectrolytes
    Photonic crystals
    Optical monitoring
    Nanoporous anodic alumina
    Physics, applied
    Nanoscience & nanotechnology
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    General materials science
    General chemical engineering
    Engenharias ii
    Chemistry, multidisciplinary
    Chemical engineering (miscellaneous)
    Chemical engineering (all)
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