Autor según el artículo: Bertran, Laia; Pastor, Angela; Portillo-Carrasquer, Marta; Binetti, Jessica; Aguilar, Carmen; Martinez, Salome; Vives, Margarita; Sabench, Fatima; Porras, Jose Antonio; Riesco, David; Del Castillo, Daniel; Richart, Cristobal; Auguet, Teresa
Departamento: Medicina i Cirurgia
Autor/es de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Del Castillo Déjardin, Daniel / Martínez González, María Salomé / Pastor Alcaraz, Ana / Porras Ledantes, Jose Antonio / Richart Jurado, Cristobal Manuel / Riesco Acevedo, David Gerardo / Sabench Pereferrer, Fàtima / VIVES GAR
Palabras clave: Transcriptome Toll-like receptors Toll-like receptor 9 Tlr9 protein, human Runx1 protein, human Runx1 Rna, messenger Obesity, morbid Non-alcoholic fatty liver disease Nafld Metabolism Liver Lipid metabolism Jejunum Humans Gut–liver axis Female Core binding factor alpha 2 subunit Adult pathophysiology nafld metabolism liver jejunum inflammation gut-liver axis gut microbiota growth-factor gene-expression cells
Resumen: The pathogenic mechanisms underlying nonalcoholic fatty liver disease (NAFLD) are beginning to be understood. RUNX1 is involved in angiogenesis, which is crucial in inflammation, but its role in nonalcoholic steatohepatitis (NASH) remains unclear. The aim of this study was to analyze RUNX1 mRNA hepatic and jejunal abundance in women with morbid obesity (MO) and NAFLD. RUNX1, lipid metabolism-related genes, and TLRs in women with MO and normal liver (NL, n = 28), NAFLD (n = 41) (simple steatosis (SS, n = 24), or NASH (n = 17)) were analyzed by RT-qPCR. The RUNX1 hepatic expression was higher in SS than in NL or NASH, as likewise confirmed by immunohistochemistry. An increased expression of hepatic FAS was found in NAFLD. Hepatic RUNX1 correlated positively with FAS. There were no significant differences in the jejunum RUNX1 expressions in the different groups. Jejunal FXR expression was lower in NASH than in NL, while the TLR9 expression increased as NAFLD progressed. Jejunal RUNX1 correlated positively with jejunal PPARγ, TLR4, and TLR5. In summary, the hepatic expression of RUNX1 seems to be involved in the first steps of the NAFLD process; however, in NASH, it seems to be downregulated. Our findings provide important insights into the role of RUNX1 in the context of NAFLD/NASH, suggesting a protective role.
Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: ana.pastor@urv.cat davidgerardo.riesco@urv.cat joseantonio.porras@urv.cat mariasalome.martinez@urv.cat danieldel.castillo@urv.cat jessicaangela.binetti@estudiants.urv.cat ana.pastor@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Identificador del autor: 0000-0001-6418-1822 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9660-7752 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/1422-0067/22/10/5239
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 22 (10): 5239-
Referencia de l'ítem segons les normes APA: Bertran, Laia; Pastor, Angela; Portillo-Carrasquer, Marta; Binetti, Jessica; Aguilar, Carmen; Martinez, Salome; Vives, Margarita; Sabench, Fatima; Por (2021). The potential protective role of runx1 in nonalcoholic fatty liver disease. International Journal Of Molecular Sciences, 22(10), 5239-. DOI: 10.3390/ijms22105239
DOI del artículo: 10.3390/ijms22105239
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications