Autor según el artículo: Yuste, Silvia; Ludwig, Iziar A.; Romero, Maria-Paz; Pinol-Felis, Carme; Catalan, Ursula; Pedret, Anna; Valls, Rosa M.; Fernandez-Castillejo, Sara; Motilva, Maria-Jose; Macia, Alba; Rubio, Laura;
Departamento: Medicina i Cirurgia
Autor/es de la URV: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Pedret Figuerola, Anna / Valls Zamora, Rosa Maria
Palabras clave: Vitro bio-accessibility Uplc-ms/ms Sustained intake Red-fleshed apple Polyphenols Phenolic compounds Melanocarpa fruit juice In-vitro Extract Dihydrochalcone metabolism Bowman's space Atherosclerosis Aortic thickness Antioxidant activity Anthocyanins Adipose-tissue
Resumen: The present study aims to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats are fed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W), or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis, and phenol biological metabolites are determined. Plasma, urine, and feces show a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan-3-ols are significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect sobserved after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function is improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) is also observed. The findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan-3-ols, together with dihydrochalcones, compose a phenolic phytocomplex in red- and white-fleshed apples, respectively, which can act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.
Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: ursula.catalan@urv.cat anna.pedret@urv.cat rosamaria.valls@urv.cat
Identificador del autor: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-3351-0942
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202001225
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 65 (10):
Referencia de l'ítem segons les normes APA: Yuste, Silvia; Ludwig, Iziar A.; Romero, Maria-Paz; Pinol-Felis, Carme; Catalan, Ursula; Pedret, Anna; Valls, Rosa M.; Fernandez-Castillejo, Sara; Mot (2021). Metabolic Fate and Cardiometabolic Effects of Phenolic Compounds from Red-Fleshed Apple in Hypercholesterolemic Rats: A Comparative Study with Common White-Fleshed Apple: The AppleCOR Study. Molecular Nutrition & Food Research, 65(10), -. DOI: 10.1002/mnfr.202001225
DOI del artículo: 10.1002/mnfr.202001225
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV