Articles producció científica> Bioquímica i Biotecnologia

Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity

  • Datos identificativos

    Identificador: imarina:9216858
    Handle: http://hdl.handle.net/20.500.11797/imarina9216858
  • Autores:

    Papandreou, Christopher
    Garcia-Gavilan, Jesus
    Camacho-Barcia, Lucia
    Hansen, Thea T.
    Sjodin, Anders
    Harrold, Joanne A.
    Halford, Jason C. G.
    Bullo, Monica
  • Otros:

    Autor según el artículo: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Hansen, Thea T.; Sjodin, Anders; Harrold, Joanne A.; Halford, Jason C. G.; Bullo, Monica;
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Bulló Bonet, Mònica
    Palabras clave: Satin Obesity Metabolomics Lean mass Insulin-resistance Fat mass Disease Body composition
    Resumen: The interplay between fat mass and lean mass within human metabolism is not completely understood. We aimed to identify specific circulating metabolomic profiles associated with these body composition compartments. Cross-sectional analyses were conducted over 236 adults with overweight/obesity from the Satiety Innovation (SATIN) study. Body composition was assessed by dual-energy X-ray absorptiometry. A targeted multiplatform metabolite profiling approach was applied. Associations between 168 circulating metabolites and the body composition measures were assessed using elastic net regression analyses. The accuracy of the multimetabolite weighted models was evaluated using a 10-fold cross-validation approach and the Pearson's correlation coefficients between metabolomic profiles and body compartments were estimated. Two different profiles including 86 and 65 metabolites were selected for % body fat and lean mass. These metabolites mainly consisted of lipids (sphingomyelins, phosphatidylcholines, lysophosphatidylcholines), acylcarnitines, and amino acids. Several metabolites overlapped between these body composition measures but none of them towards the same direction. The Pearson correlation coefficients between the metabolomic profiles and % body fat or lean mass were 0.80 and 0.79, respectively. Our findings suggest alterations in lipid metabolism, fatty acid oxidation, and protein degradation with increased adiposity and decreased lean body mass. These findings could help us to better understand the interplay between body composition compartments with human metabolic processes.
    Áreas temáticas: Molecular biology Medicina ii Farmacia Endocrinology, diabetes and metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry & molecular biology Biochemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: monica.bullo@urv.cat
    Identificador del autor: 0000-0002-0218-7046
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2218-1989/11/5/317
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Metabolites. 11 (5):
    Referencia de l'ítem segons les normes APA: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Hansen, Thea T.; Sjodin, Anders; Harrold, Joanne A.; Halford, Jason C. G.; Bull (2021). Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity. Metabolites, 11(5), -. DOI: 10.3390/metabo11050317
    DOI del artículo: 10.3390/metabo11050317
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Biochemistry & Molecular Biology,Endocrinology, Diabetes and Metabolism,Molecular Biology
    Satin
    Obesity
    Metabolomics
    Lean mass
    Insulin-resistance
    Fat mass
    Disease
    Body composition
    Molecular biology
    Medicina ii
    Farmacia
    Endocrinology, diabetes and metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biochemistry & molecular biology
    Biochemistry
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