Autor según el artículo: Harms K; Surup F; Stadler M; Stchigel AM; Marin‐felix Y

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: MARÍN FÉLIX, YASMINA / Stchigel Glikman, Alberto Miguel

Palabras clave: Sordariales ascomycota Sordariales Secondary metabolites Schizotheciaceae Morinagamyces Morinagadepsin Depsipeptide Cytotoxicity systematics sordariales secondary metabolites schizotheciaceae ribosomal dna reevaluation protein phylogeny performance morinagamyces morinagadepsin lasiosphaeriaceae diversity depsipeptide configuration

Resumen: The new genus Morinagamyces is introduced herein to accommodate the fungus Api-osordaria vermicularis as inferred from a phylogenetic study based on sequences of the internal tran-scribed spacer region (ITS), the nuclear rDNA large subunit (LSU), and partial fragments of riboso-mal polymerase II subunit 2 (rpb2) and β‐tubulin (tub2) genes. Morinagamyces vermicularis was analyzed for the production of secondary metabolites, resulting in the isolation of a new depsipeptide named morinagadepsin (1), and the already known chaetone B (3). While the planar structure of 1 was elucidated by extensive 1D‐ and 2D‐NMR analysis and high‐resolution mass spectrometry, the absolute configuration of the building blocks Ala, Val, and Leu was determined as ‐L by Marfey’s method. The configuration of the 3‐hydroxy‐2‐methyldecanyl unit was assigned as 22R,23R by J‐ based configuration analysis and Mosher’s method after partial hydrolysis of the morinagadepsin to the linear derivative compound 2. Compound 1 showed cytotoxic activity against the mammalian cell lines KB3.1 and L929, but no antimicrobial activity against the fungi and bacteria tested was observed, while 2 was inactive. Compound 3 was weakly cytotoxic against the cell line L929, but did not show any antimicrobial activity.

Áreas temáticas: Virology Microbiology (medical) Microbiology

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: albertomiguel.stchigel@urv.cat

Identificador del autor: 0000-0003-3987-7996

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2076-2607/9/6/1191

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Microorganisms. 9 (6):

Referencia de l'ítem segons les normes APA: Harms K; Surup F; Stadler M; Stchigel AM; Marin‐felix Y (2021). Morinagadepsin, a depsipeptide from the fungus morinagamyces vermicularis gen. Et comb. nov.. Microorganisms, 9(6), -. DOI: 10.3390/microorganisms9061191

DOI del artículo: 10.3390/microorganisms9061191

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications