Autor según el artículo: Ruskovska, Tatjana; Budic-Leto, Irena; Corral-Jara, Karla Fabiola; Ajdzanovic, Vladimir; Arola-Arnal, Anna; Bravo, Francisca Isabel; Deligiannidou, Georgia-Eirini; Havlik, Jaroslav; Janeva, Milkica; Kistanova, Elena; Kontogiorgis, Christos; Krga, Irena; Massaro, Marika; Miler, Marko; Milosevic, Verica; Morand, Christine; Scoditti, Egeria; Suarez, Manuel; Vauzour, David; Milenkovic, Dragan;

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Arola Arnal, Anna / Bravo Vázquez, Francisca Isabel / Suárez Recio, Manuel

Palabras clave: Transcription factor rela Tnf signaling Systematic literature search Stat1 protein Sirtuin 1 Signal transduction Rna, messenger Real-time polymerase chain reaction Real time polymerase chain reaction Protein c jun Protective agents Protective agent Ppar signaling Polyphenols Polyphenol Pi3k/akt signaling Peroxisome proliferator activated receptor Oxidative stress Olive oil polyphenols Nutritional physiological phenomena Nutrition Nutrigenomics Nonhuman Middle aged Micrornas Microrna Metabolic syndrome x Metabolic syndrome Messenger rna Mapk signaling Male Integrative bioinformatics Insulin-resistance In-vivo Immunoglobulin enhancer binding protein Humans Human Genetics Genes Gene expression Female Expression Endothelial-cells Dietary-intake Computational biology Cardiometabolic risk factors Cardiometabolic risk Cardiometabolic health Blood mononuclear-cells Blood cell Blood Biology Bioinformatics Article Adult Adipose-tissue

Resumen: Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: franciscaisabel.bravo@urv.cat anna.arola@urv.cat manuel.suarez@urv.cat

Identificador del autor: 0000-0002-6468-3088 0000-0001-6529-1345 0000-0003-0122-8253

Fecha de alta del registro: 2023-02-23

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6643/13/7/2326

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 13 (7):

Referencia de l'ítem segons les normes APA: Ruskovska, Tatjana; Budic-Leto, Irena; Corral-Jara, Karla Fabiola; Ajdzanovic, Vladimir; Arola-Arnal, Anna; Bravo, Francisca Isabel; Deligiannidou, Ge (2021). Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies. Nutrients, 13(7), -. DOI: 10.3390/nu13072326

DOI del artículo: 10.3390/nu13072326

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications