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Effects of the Mediterranean Diet or Nut Consumption on Gut Microbiota Composition and Fecal Metabolites and their Relationship with Cardiometabolic Risk Factors

  • Datos identificativos

    Identificador: imarina:9226398
    Autores:
    Galie, SerenaGarcia-Gavilan, JesusCamacho-Barcia, LuciaAtzeni, AlessandroMuralidharan, JananeePapandreou, ChristopherArcelin, PierrePalau-Galindo, AntoniGarcia, DavidBasora, JosepArias-Vasquez, AlejandroBullo, Monica
    Resumen:
    Scope To examine whether a Mediterranean Diet (MedDiet) compared to the consumption of nuts in the context of a habitual non-MedDiet exerts a greater beneficial effect on gut microbiota and fecal metabolites; thus, contributing to explain major benefits on cardiometabolic risk factors. Methods and Results Fifty adults with Metabolic Syndrome are randomized to a controlled, crossover 2-months dietary-intervention trial with a 1-month wash-out period, following a MedDiet or consuming nuts (50 g day(-1)). Microbiota composition is assessed by 16S rRNA gene sequencing and metabolites are measured using Nuclear Magnetic Resonance (NMR) and liquid chromatography coupled to triple quadrupole mass spectrometry (LC-qTOF) platforms in a targeted metabolomics approach. Decreased glucose, insulin and the homeostatic model assessment of insulin resistance (HOMA-IR) is observed after the MedDiet compared to the nuts intervention. Relative abundances of Lachnospiraceae NK4A136 and an uncultured genera of Ruminococcaceae are significantly increased after the MedDiet compared to nuts supplementation. Changes in Lachnospiraceae NK4A136 are inversely associated with insulin levels and HOMA-IR, while positively and negatively with changes in cholate and cadaverine, respectively. Conclusions Following a MedDiet, rather than nuts, induces a significant increase in Lachnospiraceae NK4A136 and improves the metabolic risk. This genera seems to affect the bile acid metabolism and cadaverine which may account for the improvement in insulin levels.
  • Otros:

    Autor según el artículo: Galie, Serena; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Atzeni, Alessandro; Muralidharan, Jananee; Papandreou, Christopher; Arcelin, Pierre; Palau-Galindo, Antoni; Garcia, David; Basora, Josep; Arias-Vasquez, Alejandro; Bullo, Monica
    Departamento: Dret Públic
    Autor/es de la URV: Atzeni, Alessandro / Bulló Bonet, Mònica / Galiè, Serena / García Gavilán, Jesús Francisco / Muralidharan, Jananee / Palau Galindo, Antonio
    Palabras clave: Walnuts Pistachio consumption Nuts Modulation Middle aged Metabolome Mediterranean diet Insulin resistance Insulin Humans Gut microbiota Gastrointestinal microbiome Feces Fecal metabolites Diet, mediterranean Cholesterol Cardiometabolic risk factors
    Resumen: Scope To examine whether a Mediterranean Diet (MedDiet) compared to the consumption of nuts in the context of a habitual non-MedDiet exerts a greater beneficial effect on gut microbiota and fecal metabolites; thus, contributing to explain major benefits on cardiometabolic risk factors. Methods and Results Fifty adults with Metabolic Syndrome are randomized to a controlled, crossover 2-months dietary-intervention trial with a 1-month wash-out period, following a MedDiet or consuming nuts (50 g day(-1)). Microbiota composition is assessed by 16S rRNA gene sequencing and metabolites are measured using Nuclear Magnetic Resonance (NMR) and liquid chromatography coupled to triple quadrupole mass spectrometry (LC-qTOF) platforms in a targeted metabolomics approach. Decreased glucose, insulin and the homeostatic model assessment of insulin resistance (HOMA-IR) is observed after the MedDiet compared to the nuts intervention. Relative abundances of Lachnospiraceae NK4A136 and an uncultured genera of Ruminococcaceae are significantly increased after the MedDiet compared to nuts supplementation. Changes in Lachnospiraceae NK4A136 are inversely associated with insulin levels and HOMA-IR, while positively and negatively with changes in cholate and cadaverine, respectively. Conclusions Following a MedDiet, rather than nuts, induces a significant increase in Lachnospiraceae NK4A136 and improves the metabolic risk. This genera seems to affect the bile acid metabolism and cadaverine which may account for the improvement in insulin levels.
    Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: antonio.palau@urv.cat jesusfrancisco.garcia@urv.cat alessandro.atzeni@urv.cat jesusfrancisco.garcia@urv.cat alessandro.atzeni@urv.cat monica.bullo@urv.cat
    Identificador del autor: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0002-0218-7046
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000982
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 65 (19): 2000982-
    Referencia de l'ítem segons les normes APA: Galie, Serena; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Atzeni, Alessandro; Muralidharan, Jananee; Papandreou, Christopher; Arcelin, Pierre; Pala (2021). Effects of the Mediterranean Diet or Nut Consumption on Gut Microbiota Composition and Fecal Metabolites and their Relationship with Cardiometabolic Risk Factors. Molecular Nutrition & Food Research, 65(19), 2000982-. DOI: 10.1002/mnfr.202000982
    DOI del artículo: 10.1002/mnfr.202000982
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biotechnology,Food Science,Food Science & Technology
    Walnuts
    Pistachio consumption
    Nuts
    Modulation
    Middle aged
    Metabolome
    Mediterranean diet
    Insulin resistance
    Insulin
    Humans
    Gut microbiota
    Gastrointestinal microbiome
    Feces
    Fecal metabolites
    Diet, mediterranean
    Cholesterol
    Cardiometabolic risk factors
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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