Autor según el artículo: Trapani, Mariachiara; Scala, Angela; Mineo, Placido G; Pistone, Alessandro; Diaz-Moscoso, Alejandro; Fragoso, Alex; Scolaro, Luigi Monsu; Mazzaglia, Antonino
Departamento: Enginyeria Química
Autor/es de la URV: Fragoso Sierra, Alex
Palabras clave: Nanovesicles Hybrid assemblies Gold colloids Dopamine Cyclic voltammetry Blood-brain-barrier Amphiphilic cyclodextrins vesicles polydisperse polymers perspectives particles nanovesicles nanostructures nanoparticles hybrid assemblies gold colloids dopamine delivery cyclic voltammetry complexes blends
Resumen: We report a hybrid nanoassembly based on gold colloids decorated with a new thiolated amphiphilic cyclodextrin complexing dopamine (AuNPs@SC16SH/DA). The novel amphiphilic β-cyclodextrin SC16SH, bearing on average one thiol group at the end of an oligoethylene glycol chain per CyD unit, was obtained in a multi-step synthesis and fully characterized by NMR spectroscopy and MALDI analysis. The AuNPs@SC16SH hybrid assembly was prepared by mixing AuNPs and SC16SH in aqueous solution and investigated by UV/Vis and TEM measurements. The AuNPs@SC16SH/DA supramolecular assembly, bearing both thiol-stabilized gold nanoparticles and the neurotransmitter dopamine, has been conceived as stimuli-responsive delivery system able to control the release of dopamine upon proper stimuli. Two redox functionalities (i.e. the Au-S bond and the redox behaviour of dopamine) have been exploited to detach SC16SH/DA complex from the AuNPs@SC16SH/DA progenitor platform, using dithiothreitol (DTT), and to detect the complex by cyclic voltammetry (CV). Following, dopamine was finally released from the SC16SH/DA assembly upon treatment with Brij® S20 and the free dopamine was monitored by CV. Overall, our hybrid nanoassemblies turned out to be able to release dopamine, upon combined action of redox and digestion agents in medium emulating biological environment.
Áreas temáticas: Spectroscopy Química Physics, atomic, molecular & chemical Physical and theoretical chemistry Medicina ii Materials chemistry Materiais Interdisciplinar Farmacia Engenharias iii Engenharias ii Electronic, optical and magnetic materials Condensed matter physics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Chemistry, physical Biotecnología Atomic and molecular physics, and optics Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: alex.fragoso@urv.cat
Identificador del autor: 0000-0003-4839-6094
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0167732221016044
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of Molecular Liquids. 336 116880-
Referencia de l'ítem segons les normes APA: Trapani, Mariachiara; Scala, Angela; Mineo, Placido G; Pistone, Alessandro; Diaz-Moscoso, Alejandro; Fragoso, Alex; Scolaro, Luigi Monsu; Mazzaglia, A (2021). Thiolated amphiphilic β-cyclodextrin-decorated gold colloids: Synthesis, supramolecular nanoassemblies and controlled release of dopamine. Journal Of Molecular Liquids, 336(), 116880-. DOI: 10.1016/j.molliq.2021.116880
DOI del artículo: 10.1016/j.molliq.2021.116880
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV