Autor según el artículo: Collins DR; Urbach JM; Racenet ZJ; Arshad U; Power KA; Newman RM; Mylvaganam GH; Ly NL; Lian X; Rull A; Rassadkina Y; Yanez AG; Peluso MJ; Deeks SG; Vidal F; Lichterfeld M; Yu XG; Gaiha GD; Allen TM; Walker BD
Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/es de la URV: RULL AIXA, ANNA / Vidal Marsal, Francisco
Palabras clave: Human immunology Hiv control Cd8(+) t-cells Cd8 t cell dysfunction + sequence alignment responses replication pd-1 infection expression exhaustion ex-vivo activation
Resumen: Spontaneous control of HIV infection has been repeatedly linked to antiviral CD8+ T cells but is not always permanent. To address mechanisms of durable and aborted control of viremia, we evaluated immunologic and virologic parameters longitudinally among 34 HIV-infected subjects with differential outcomes. Despite sustained recognition of autologous virus, HIV-specific proliferative and cytolytic T cell effector functions became selectively and intrinsically impaired prior to aborted control. Longitudinal transcriptomic profiling of functionally impaired HIV-specific CD8+ T cells revealed altered expression of genes related to activation, cytokine-mediated signaling, and cell cycle regulation, including increased expression of the antiproliferative transcription factor KLF2 but not of genes associated with canonical exhaustion. Lymphoid HIV-specific CD8+ T cells also exhibited poor functionality during aborted control relative to durable control. Our results identify selective functional impairment of HIV-specific CD8+ T cells as prognostic of impending aborted HIV control, with implications for clinical monitoring and immunotherapeutic strategies.
Áreas temáticas: Medicina ii Medicina i Infectious diseases Immunology and allergy Immunology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: francesc.vidal@urv.cat
Identificador del autor: 0000-0002-6692-6186
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.cell.com/immunity/fulltext/S1074-7613(21)00337-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS107476132100337X%3Fshowall%3Dtrue#%20
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Immunity. 54 (10): 2372-2384.e7
Referencia de l'ítem segons les normes APA: Collins DR; Urbach JM; Racenet ZJ; Arshad U; Power KA; Newman RM; Mylvaganam GH; Ly NL; Lian X; Rull A; Rassadkina Y; Yanez AG; Peluso MJ; Deeks SG; V (2021). Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia. Immunity, 54(10), 2372-2384.e7. DOI: 10.1016/j.immuni.2021.08.007
DOI del artículo: 10.1016/j.immuni.2021.08.007
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV