Autor según el artículo: Miralles-Pérez B; Méndez L; Nogués MR; Sánchez-Martos V; Fortuño-Mar À; Ramos-Romero S; Hereu M; Medina I; Romeu M
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Miralles Pérez, Bernat / Nogués Llort, Maria Rosa / Romeu Ferran, Marta / Sánchez Martos, Vanessa
Palabras clave: Soybean oil Protein carbonylation Polyunsaturated fatty-acids Lipid peroxidation Inflammation Glucose Eicosapentaenoic acid Coconut oil Cholesterol supplementation soybean oil protein carbonylation polyphenols plasma omega-3 pufas lipid peroxidation inflammation glutathione glucose eicosapentaenoic acid diet coconut oil cholesterol cardiovascular-disease
Resumen: Omega-3 polyunsaturated fatty acids are associated with a lower risk of cardiometabolic diseases. However, docosahexaenoic acid (DHA) is easily oxidized, leading to cellular damage. The present study examined the effects of an increased concentration of DHA in fish oil (80% of total fatty acids) on cardiometabolic risk factors and oxidative stress compared to coconut oil, soybean oil, and fish oil containing eicosapentaenoic acid (EPA) and DHA in a balanced ratio. Forty healthy male Sprague–Dawley rats were supplemented with corresponding oil for 10 weeks. Supplementation with the fish oil containing 80% DHA decreased plasma fat, plasma total cholesterol and muscle fat compared to the coconut oil and the soybean oil. Increasing concentrations of DHA induced incorporation of DHA and EPA in cell membranes and tissues along with a decrease in ω-6 arachidonic acid. The increase in DHA promoted lipid peroxidation, protein carbonylation and antioxidant response. Taken together, the increased concentration of DHA in fish oil reduced fat accumulation compared to the coconut oil and the soybean oil. This benefit was accompanied by high lipid peroxidation and subsequent protein carbonylation in plasma and in liver. In our healthy framework, the slightly higher carbonylation found after receiving fish oil containing 80% DHA might be a protecting mechanism, which fit with the general improvement of antioxidant defense observed in those rats.
Áreas temáticas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: vanessa.sanchez@urv.cat bernat.miralles@urv.cat vanessa.sanchez@urv.cat marta.romeu@urv.cat
Identificador del autor: 0000-0003-1294-7069 0000-0002-2131-1858
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/1660-3397/19/10/555
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Marine Drugs. 19 (10):
Referencia de l'ítem segons les normes APA: Miralles-Pérez B; Méndez L; Nogués MR; Sánchez-Martos V; Fortuño-Mar À; Ramos-Romero S; Hereu M; Medina I; Romeu M (2021). Effects of a fish oil rich in docosahexaenoic acid on cardiometabolic risk factors and oxidative stress in healthy rats. Marine Drugs, 19(10), -. DOI: 10.3390/md19100555
DOI del artículo: 10.3390/md19100555
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications