Autor según el artículo: Moreno-Vedia, J; Rosales, R; Ozcariz, E; Llop, D; Lahuerta, M; Benavent, M; Rodriguez-Calvo, R; Plana, N; Pedragosa, A; Masana, L; Castro, A; Ibarretxe, D; Girona, J
Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: Castro Salomó, Antoni / Girona Tell, Josefa / Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / Moreno Vedia, Juan / Plana Gil, Núria / Rodríguez Calvo, Ricardo / ROSALES RIBAS, ROSER
Palabras clave: Triglyceride-rich lipoproteins Steatosis Simple noninvasive index Significant fibrosis Risk Overproduction Nonalcoholic steatohepatitis Nmr Metabolic-associated fatty liver disease Mechanisms Glycosylation Glycoproteins Epidemiology Cardiovascular risk Biomarker
Resumen: High plasma triglyceride (TG) levels and chronic inflammation are important factors related to metabolic-associated fatty liver disease in patients at cardiovascular risk. Using nuclear magnetic resonance (H-1-NMR), we aimed to study the triglyceride-rich lipoprotein (TRL) and acute-phase glycoprotein profiles of a cohort of patients with metabolic disease and their relationship with fatty liver. Plasma samples of 280 patients (type 2 diabetes, 81.1%; obesity, 63.3%; and metabolic syndrome, 91.8%) from the University Hospital Lipid Unit were collected for the measurement of small, medium and large TRL particle numbers and sizes and glycoprotein profiles (Glyc-A and Glyc-B) by H-1-NMR. Liver function parameters, including the fatty liver index (FLI) and fibrosis-4 (FIB-4) score, were assessed. Hepatic echography assessment was performed in 100 patients, and they were followed up for 10 years. TRL particle concentrations showed a strong positive association with Glyc-A and Glyc-B (rho=0.895 and rho=0.654, p<0.001, respectively) and with the liver function-related proteins ALT rho=0.293, p<0.001), AST (rho=0.318, p<0.001) and GGT (rho=0.284, p<0.001). Likewise, TRL concentrations showed a positive association with FLI (rho=0.425, p<0.001) but not with FIB-4. During the follow-up period of 10 years, 18 new cases of steatosis were observed among 64 patients who were disease-free at baseline. Baseline TRL particle numbers and glycoprotein levels were associated with the new development of metabolic-associated fatty liver disease (MAFLD) (AUC=0.692, p=0.018 and AUC=0.669, p=0.037, respectively). Overall, our results indicated that TRL number and acute-phase glycoproteins measured by H-1-NMR could be potential biomarkers of the development of hepatic steatosis in patients at metabolic risk.
Áreas temáticas: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: didac.llop@urv.cat daiana.ibarretxe@urv.cat josefa.girona@urv.cat ricardo.rodriguez@urv.cat didac.llop@urv.cat josefa.girona@urv.cat antoni.castro@urv.cat luis.masana@urv.cat juan.moreno@estudiants.urv.cat juan.moreno@estudiants.urv.cat
Identificador del autor: 0000-0002-6267-8779 0000-0002-6267-8779 0000-0001-5441-6333 0000-0002-0789-4954 0000-0002-2673-3822 0000-0002-2673-3822
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Frontiers In Endocrinology. 12
Referencia de l'ítem segons les normes APA: Moreno-Vedia, J; Rosales, R; Ozcariz, E; Llop, D; Lahuerta, M; Benavent, M; Rodriguez-Calvo, R; Plana, N; Pedragosa, A; Masana, L; Castro, A; Ibarretx (2022). Triglyceride-Rich Lipoproteins and Glycoprotein A and B Assessed by 1H-NMR in Metabolic-Associated Fatty Liver Disease. Frontiers In Endocrinology, 12(), -. DOI: 10.3389/fendo.2021.775677
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV