Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A  ulti-Centre Population-Based Birth Cohort Study in Spain

Autor según el artículo: Tahaei, Hana; Gignac, Florence; Pinar, Ariadna; Fernandez-Barres, Silvia; Romaguera, Dora; Vioque, Jesus; Santa-Marina, Loreto; Subiza-Perez, Mikel; Llop, Sabrina; Soler-Blasco, Raquel; Arija, Victoria; Salas-Salvado, Jordi; Tardon, Adonina; Riano-Galan, Isolina; Sunyer, Jordi; Guxens, Monica; Julvez, Jordi

Departamento: Ciències Mèdiques Bàsiques; Bioquímica i Biotecnologia

Autor/es de la URV: Arija Val, Maria Victoria / Salas Salvadó, Jorge

Palabras clave: Spain; Prospective studies; Prenatal exposure delayed effects; Pregnancy; Population-based cohort; Polyunsaturated fatty-acids; Omega-3 fatty acids; Neurodevelopment; Maternal diet; Infant; Humans; Female; Fatty acids, omega-3; Cohort studies; Children; Child, preschool; Child development; Child; Birth cohort; seafood; population-based cohort; omega-3 fatty acids; neurodevelopmental outcomes; neurodevelopment; energy; diet; consumption; children

Resumen: Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child’s neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children’s Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/week) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/week) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI:-22.95,-0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings.

Áreas temáticas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: jordi.salas@urv.cat; victoria.arija@urv.cat

Fecha de alta del registro: 2025-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6643/14/3/518

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 14 (3): 518-

Referencia de l'ítem segons les normes APA: Tahaei, Hana; Gignac, Florence; Pinar, Ariadna; Fernandez-Barres, Silvia; Romaguera, Dora; Vioque, Jesus; Santa-Marina, Loreto; Subiza-Perez, Mikel; L (2022). Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A  ulti-Centre Population-Based Birth Cohort Study in Spain. Nutrients, 14(3), 518-. DOI: 10.3390/nu14030518

DOI del artículo: 10.3390/nu14030518

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2022

Tipo de publicación: Journal Publications