Articles producció científica> Medicina i Cirurgia

Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study

  • Datos identificativos

    Identificador: imarina:9246565
    Autores:
    Wendel-Garcia PDMas AGonzález-Isern CFerrer RMáñez RMasclans JRSandoval EVera PTrenado JFernández RSirvent JMMartínez MIbarz MGarro PLopera JLBodí MYébenes-Reyes JCTriginer CVallverdú IBaró ABodí FSaludes PValencia MRoche-Campo FHuerta ACambra FJBarberà CEchevarria JPeñuelas ÓMancebo JFerrer RRoca ONuvials XRuiz JCPapiol EMáñez RGumicio VDSandoval EMuñoz GToapanta DCastro POsorio JMasclans JRMuñoz-Bermúdez RParrilla FPérez-Teran PMarin-Corral JMas ACancio BHernández-Marín SKoborzan MRBriones CATrenado JFernández RSirvent JMSebastian PSaiz XMartínez MIbarz MGarro PPedrós CVendrell ELopera JLBodí MRodríguez AMoreno GYébenes-Reves JCTriginer CVallverdú IBaró AMorales MBodí FSaludes PCervelló JRValencia MRoche-Campo FFranch-Llasat DHuerta ASantigosa PCambra FJBenito SBarberà CEchevarría JMancebo JVera PSantos JABaldirà JBetbesé AJIzura MMorán ISuárez JCZapata LRodríguez NTorrens MCordón AGomila CFlores MSegarra AMorales MMateo LMartos M & González-Isern C
    Resumen:
    Background: Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during the coronavirus disease 2019 (COVID-19). While the efficacy of these therapies has been studied in hospitalized patients with COVID-19, the clinical outcomes associated with oxygen masks, high-flow oxygen therapy by nasal cannula and non-invasive mechanical ventilation in critically ill intensive care unit (ICU) patients remain unclear. Methods: In this retrospective study, we used the best of nine covariate balancing algorithms on all baseline covariates in critically ill COVID-19 patients supported with > 10 L of supplemental oxygen at one of the 26 participating ICUs in Catalonia, Spain, between March 14 and April 15, 2020. Results: Of the 1093 non-invasively oxygenated patients at ICU admission treated with one of the three stand-alone non-invasive oxygenation strategies, 897 (82%) required endotracheal intubation and 310 (28%) died during the ICU stay. High-flow oxygen therapy by nasal cannula (n = 439) and non-invasive mechanical ventilation (n = 101) were associated with a lower rate of endotracheal intubation (70% and 88%, respectively) than oxygen masks (n = 553 and 91% intubated), p < 0.001. Compared to oxygen masks, high-flow oxygen therapy by nasal cannula was associated with lower ICU mortality (hazard ratio 0.75 [95% CI 0.58–0.98), and the hazard ratio for ICU mortality was 1.21 [95% CI 0.80–1.83] for non-invasive mechanical ventilation. Conclusion: In critically ill COVID-19 ICU patients and, in the absence of conclusive data, high-flow oxygen therapy by nasal cannula may be the approach of choice as the primary non-invasive oxygenation support strategy.
  • Otros:

    Autor según el artículo: Wendel-Garcia PD; Mas A; González-Isern C; Ferrer R; Máñez R; Masclans JR; Sandoval E; Vera P; Trenado J; Fernández R; Sirvent JM; Martínez M; Ibarz M; Garro P; Lopera JL; Bodí M; Yébenes-Reyes JC; Triginer C; Vallverdú I; Baró A; Bodí F; Saludes P; Valencia M; Roche-Campo F; Huerta A; Cambra FJ; Barberà C; Echevarria J; Peñuelas Ó; Mancebo J; Ferrer R; Roca O; Nuvials X; Ruiz JC; Papiol E; Máñez R; Gumicio VD; Sandoval E; Muñoz G; Toapanta D; Castro P; Osorio J; Masclans JR; Muñoz-Bermúdez R; Parrilla F; Pérez-Teran P; Marin-Corral J; Mas A; Cancio B; Hernández-Marín S; Koborzan MR; Briones CA; Trenado J; Fernández R; Sirvent JM; Sebastian P; Saiz X; Martínez M; Ibarz M; Garro P; Pedrós C; Vendrell E; Lopera JL; Bodí M; Rodríguez A; Moreno G; Yébenes-Reves JC; Triginer C; Vallverdú I; Baró A; Morales M; Bodí F; Saludes P; Cervelló JR; Valencia M; Roche-Campo F; Franch-Llasat D; Huerta A; Santigosa P; Cambra FJ; Benito S; Barberà C; Echevarría J; Mancebo J; Vera P; Santos JA; Baldirà J; Betbesé AJ; Izura M; Morán I; Suárez JC; Zapata L; Rodríguez N; Torrens M; Cordón A; Gomila C; Flores M; Segarra A; Morales M; Mateo L; Martos M & González-Isern C
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Bodi Saera, Maria Amparo
    Palabras clave: Non-invasive oxygenation Intensive care Covid-19 Acute hypoxemic respiratory failure
    Resumen: Background: Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during the coronavirus disease 2019 (COVID-19). While the efficacy of these therapies has been studied in hospitalized patients with COVID-19, the clinical outcomes associated with oxygen masks, high-flow oxygen therapy by nasal cannula and non-invasive mechanical ventilation in critically ill intensive care unit (ICU) patients remain unclear. Methods: In this retrospective study, we used the best of nine covariate balancing algorithms on all baseline covariates in critically ill COVID-19 patients supported with > 10 L of supplemental oxygen at one of the 26 participating ICUs in Catalonia, Spain, between March 14 and April 15, 2020. Results: Of the 1093 non-invasively oxygenated patients at ICU admission treated with one of the three stand-alone non-invasive oxygenation strategies, 897 (82%) required endotracheal intubation and 310 (28%) died during the ICU stay. High-flow oxygen therapy by nasal cannula (n = 439) and non-invasive mechanical ventilation (n = 101) were associated with a lower rate of endotracheal intubation (70% and 88%, respectively) than oxygen masks (n = 553 and 91% intubated), p < 0.001. Compared to oxygen masks, high-flow oxygen therapy by nasal cannula was associated with lower ICU mortality (hazard ratio 0.75 [95% CI 0.58–0.98), and the hazard ratio for ICU mortality was 1.21 [95% CI 0.80–1.83] for non-invasive mechanical ventilation. Conclusion: In critically ill COVID-19 ICU patients and, in the absence of conclusive data, high-flow oxygen therapy by nasal cannula may be the approach of choice as the primary non-invasive oxygenation support strategy.
    Áreas temáticas: Saúde coletiva Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Engenharias iv Enfermagem Educação física Critical care medicine Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat
    Identificador del autor: 0000-0001-7652-8379 0000-0001-7652-8379
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://ccforum.biomedcentral.com/articles/10.1186/s13054-022-03905-5
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Critical Care. 26 (37): 1-13
    Referencia de l'ítem segons les normes APA: Wendel-Garcia PD; Mas A; González-Isern C; Ferrer R; Máñez R; Masclans JR; Sandoval E; Vera P; Trenado J; Fernández R; Sirvent JM; Martínez M; Ibarz M (2022). Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study. Critical Care, 26(37), 1-13. DOI: 10.1186/s13054-022-03905-5
    DOI del artículo: 10.1186/s13054-022-03905-5
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Critical Care and Intensive Care Medicine,Critical Care Medicine
    Non-invasive oxygenation
    Intensive care
    Covid-19
    Acute hypoxemic respiratory failure
    Saúde coletiva
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care medicine
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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