Articles producció científica> Medicina i Cirurgia

Resistin and IL-15 as Predictors of Invasive Mechanical Ventilation in COVID-19 Pneumonia Irrespective of the Presence of Obesity and Metabolic Syndrome

  • Datos identificativos

    Identificador: imarina:9246623
    Autores:
    Perpinan, CarlesBertran, LaiaTerra, XimenaAguilar, CarmenBinetti, JessicaLopez-Dupla, MiguelRull, AnnaReverte, LaiaYeregui, ElenaGomez-Bertomeu, FredericPeraire, JoaquimAuguet, Teresa
    Resumen:
    The cytokine signature present in COVID-19 could provide information on the pathogenic mechanisms of the disease and could identify possible prognostic biomarkers and possible therapeutic targets. In this longitudinal work, we studied the clinical and biochemical parameters and circulating cytokine levels of 146 patients at the time of admission for COVID-19 and 4–6 weeks later. The main objective of this study was to determine whether basal cytokines could be early prognostic biomarkers of COVID-19, and also to analyze the impact of comorbidities, such as obesity or metabolic syndrome (MS), in the cytokine profile. The levels of most inflammatory cytokines were elevated on admission in relation to the level that was reached 4–6 weeks later, except for IL-1?, which was lower on admission; these levels were irrespective of the presence of obesity or MS since the cytokine storm masks these inflammatory processes. Among the cytokines analyzed, those that correlated with a worse prognosis of COVID-19 were resistin, IL-6, IL-8, IL-15, MCP-1 and TNF-?. Specifically, resistin and IL-15 are the best early predictors of requiring invasive ventilation. Therefore, resistin and IL-15 should be included in the personalized treatment decision algorithm of patients with COVID-19.
  • Otros:

    Autor según el artículo: Perpinan, Carles; Bertran, Laia; Terra, Ximena; Aguilar, Carmen; Binetti, Jessica; Lopez-Dupla, Miguel; Rull, Anna; Reverte, Laia; Yeregui, Elena; Gomez-Bertomeu, Frederic; Peraire, Joaquim; Auguet, Teresa
    Departamento: Bioquímica i Biotecnologia Medicina i Cirurgia
    Autor/es de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Gomez Bertomeu, Frederic-Francesc / López Dupla, Jesús Miguel / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Terra Barbadora, Ximena / Yeregui Etxeberria, Elena
    Palabras clave: Sars-cov-2 Prediction Obesity Metabolic syndrome Cytokines Cytokine storm Covid-19 sars-cov-2 prediction obesity mortality metabolic syndrome cytokines
    Resumen: The cytokine signature present in COVID-19 could provide information on the pathogenic mechanisms of the disease and could identify possible prognostic biomarkers and possible therapeutic targets. In this longitudinal work, we studied the clinical and biochemical parameters and circulating cytokine levels of 146 patients at the time of admission for COVID-19 and 4–6 weeks later. The main objective of this study was to determine whether basal cytokines could be early prognostic biomarkers of COVID-19, and also to analyze the impact of comorbidities, such as obesity or metabolic syndrome (MS), in the cytokine profile. The levels of most inflammatory cytokines were elevated on admission in relation to the level that was reached 4–6 weeks later, except for IL-1?, which was lower on admission; these levels were irrespective of the presence of obesity or MS since the cytokine storm masks these inflammatory processes. Among the cytokines analyzed, those that correlated with a worse prognosis of COVID-19 were resistin, IL-6, IL-8, IL-15, MCP-1 and TNF-?. Specifically, resistin and IL-15 are the best early predictors of requiring invasive ventilation. Therefore, resistin and IL-15 should be included in the personalized treatment decision algorithm of patients with COVID-19.
    Áreas temáticas: Science and technology studies Medicine, general & internal Medicine (miscellaneous) Health care sciences & services
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat jessicaangela.binetti@estudiants.urv.cat elena.yeregui@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat ximena.terra@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat jesusmiguel.lopez@urv.cat
    Identificador del autor: 0000-0002-8039-2889 0000-0001-7808-5479 0000-0001-9660-7752 0000-0001-9052-1368 0000-0001-9052-1368 0000-0003-1043-5844 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428 0000-0002-9141-2523
    Fecha de alta del registro: 2024-09-28
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2075-4426/12/3/391
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: J Pers Med. 12 (3): 391-
    Referencia de l'ítem segons les normes APA: Perpinan, Carles; Bertran, Laia; Terra, Ximena; Aguilar, Carmen; Binetti, Jessica; Lopez-Dupla, Miguel; Rull, Anna; Reverte, Laia; Yeregui, Elena; Gom (2022). Resistin and IL-15 as Predictors of Invasive Mechanical Ventilation in COVID-19 Pneumonia Irrespective of the Presence of Obesity and Metabolic Syndrome. J Pers Med, 12(3), 391-. DOI: 10.3390/jpm12030391
    DOI del artículo: 10.3390/jpm12030391
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Health Care Sciences & Services,Medicine (Miscellaneous),Medicine, General & Internal
    Sars-cov-2
    Prediction
    Obesity
    Metabolic syndrome
    Cytokines
    Cytokine storm
    Covid-19
    sars-cov-2
    prediction
    obesity
    mortality
    metabolic syndrome
    cytokines
    Science and technology studies
    Medicine, general & internal
    Medicine (miscellaneous)
    Health care sciences & services
  • Documentos:

  • Cerca a google

    Search to google scholar