Autor según el artículo: Perpiñan, C; Bertran, L; Terra, X; Aguilar, C; Binetti, J; Lopez-Dupla, M; Rull, A; Reverté, L; Yeregui, E; Gómez-Bertomeu, F; Peraire, J; Auguet, T
Departamento: Bioquímica i Biotecnologia Medicina i Cirurgia
Autor/es de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Gomez Bertomeu, Frederic-Francesc / López Dupla, Jesús Miguel / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Terra Barbadora, Ximena / Yeregui Etxeberria, Elena
Palabras clave: Sars-cov-2 Prediction Obesity Metabolic syndrome Cytokines Cytokine storm Covid-19 sars-cov-2 prediction obesity mortality metabolic syndrome cytokines
Resumen: The cytokine signature present in COVID-19 could provide information on the pathogenic mechanisms of the disease and could identify possible prognostic biomarkers and possible therapeutic targets. In this longitudinal work, we studied the clinical and biochemical parameters and circulating cytokine levels of 146 patients at the time of admission for COVID-19 and 4–6 weeks later. The main objective of this study was to determine whether basal cytokines could be early prognostic biomarkers of COVID-19, and also to analyze the impact of comorbidities, such as obesity or metabolic syndrome (MS), in the cytokine profile. The levels of most inflammatory cytokines were elevated on admission in relation to the level that was reached 4–6 weeks later, except for IL-1?, which was lower on admission; these levels were irrespective of the presence of obesity or MS since the cytokine storm masks these inflammatory processes. Among the cytokines analyzed, those that correlated with a worse prognosis of COVID-19 were resistin, IL-6, IL-8, IL-15, MCP-1 and TNF-?. Specifically, resistin and IL-15 are the best early predictors of requiring invasive ventilation. Therefore, resistin and IL-15 should be included in the personalized treatment decision algorithm of patients with COVID-19.
Áreas temáticas: Science and technology studies Medicine (miscellaneous)
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat jesusmiguel.lopez@urv.cat mariateresa.auguet@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat ximena.terra@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat elena.yeregui@estudiants.urv.cat jessicaangela.binetti@estudiants.urv.cat
Identificador del autor: 0000-0002-8039-2889 0000-0001-7808-5479 0000-0002-9141-2523 0000-0003-0396-6428 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-1043-5844 0000-0001-9052-1368 0000-0001-9052-1368 0000-0001-9660-7752
Fecha de alta del registro: 2024-02-10
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2075-4426/12/3/391
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: J Pers Med. 12 (3): 391-
Referencia de l'ítem segons les normes APA: Perpiñan, C; Bertran, L; Terra, X; Aguilar, C; Binetti, J; Lopez-Dupla, M; Rull, A; Reverté, L; Yeregui, E; Gómez-Bertomeu, F; Peraire, J; Auguet, T (2022). Resistin and IL-15 as Predictors of Invasive Mechanical Ventilation in COVID-19 Pneumonia Irrespective of the Presence of Obesity and Metabolic Syndrome. J Pers Med, 12(3), 391-. DOI: 10.3390/jpm12030391
DOI del artículo: 10.3390/jpm12030391
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV