Articles producció científica> Medicina i Cirurgia

Identification of the Potential Molecular Mechanisms Linking RUNX1 Activity with Nonalcoholic Fatty Liver Disease, by Means of Systems Biology

  • Datos identificativos

    Identificador: imarina:9264858
    Autores:
    Bertran, LaiaEigbefoh-Addeh, AilendePortillo-Carrasquer, MartaBarrientos-Riosalido, AndreaBinetti, JessicaAguilar, CarmenChicote, Javier UgarteBartra, HelenaArtigas, LauraComa, MireiaRichart, CristobalAuguet, Teresa
    Resumen:
    Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disease; nevertheless, no definitive diagnostic method exists yet, apart from invasive liver biopsy, and nor is there a specific approved treatment. Runt‐related transcription factor 1 (RUNX1) plays a major role in angiogenesis and inflammation; however, its link with NAFLD is unclear as controversial results have been reported. Thus, the objective of this work was to determine the proteins involved in the molecular mechanisms between RUNX1 and NAFLD, by means of systems biology. First, a mathematical model that simulates NAFLD pathophysiology was generated by analyzing Anax-omics databases and reviewing available scientific literature. Artificial neural networks established NAFLD pathophysiological processes functionally related to RUNX1: hepatic insulin resistance, lipotoxicity, and hepatic injury‐liver fibrosis. Our study indicated that RUNX1 might have a high relationship with hepatic injury‐liver fibrosis, and a medium relationship with lipotoxicity and insulin resistance motives. Additionally, we found five RUNX1‐regulated proteins with a direct in-volvement in NAFLD motives, which were NFκB1, NFκB2, TNF, ADIPOQ, and IL‐6. In conclusion, we suggested a relationship between RUNX1 and NAFLD since RUNX1 seems to regulate NAFLD molecular pathways, posing it as a potential therapeutic target of NAFLD, although more studies in this field are needed.
  • Otros:

    Autor según el artículo: Bertran, Laia; Eigbefoh-Addeh, Ailende; Portillo-Carrasquer, Marta; Barrientos-Riosalido, Andrea; Binetti, Jessica; Aguilar, Carmen; Chicote, Javier Ugarte; Bartra, Helena; Artigas, Laura; Coma, Mireia; Richart, Cristobal; Auguet, Teresa
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Barrientos Riosalido, Andrea / Bertran Ramos, Laia / Binetti, Jessica Angela / Eigbefoh-Addeh Imafidon, Ailende / Richart Jurado, Cristobal Manuel
    Palabras clave: Systems biology Runx1 Protein-kinase-c Nash Nafld Metabolism systems biology reference database pathway nf-kappa-b nash nafld metabolism insulin-resistance growth-factor gene cell apoptosis alpha expression activation
    Resumen: Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disease; nevertheless, no definitive diagnostic method exists yet, apart from invasive liver biopsy, and nor is there a specific approved treatment. Runt‐related transcription factor 1 (RUNX1) plays a major role in angiogenesis and inflammation; however, its link with NAFLD is unclear as controversial results have been reported. Thus, the objective of this work was to determine the proteins involved in the molecular mechanisms between RUNX1 and NAFLD, by means of systems biology. First, a mathematical model that simulates NAFLD pathophysiology was generated by analyzing Anax-omics databases and reviewing available scientific literature. Artificial neural networks established NAFLD pathophysiological processes functionally related to RUNX1: hepatic insulin resistance, lipotoxicity, and hepatic injury‐liver fibrosis. Our study indicated that RUNX1 might have a high relationship with hepatic injury‐liver fibrosis, and a medium relationship with lipotoxicity and insulin resistance motives. Additionally, we found five RUNX1‐regulated proteins with a direct in-volvement in NAFLD motives, which were NFκB1, NFκB2, TNF, ADIPOQ, and IL‐6. In conclusion, we suggested a relationship between RUNX1 and NAFLD since RUNX1 seems to regulate NAFLD molecular pathways, posing it as a potential therapeutic target of NAFLD, although more studies in this field are needed.
    Áreas temáticas: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
    Direcció de correo del autor: ailende.eigbefoh-addeh@urv.cat andrea.barrientos@urv.cat andrea.barrientos@urv.cat jessicaangela.binetti@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
    Identificador del autor: 0000-0001-9660-7752 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
    Fecha de alta del registro: 2024-09-28
    Enlace a la fuente original: https://www.mdpi.com/2227-9059/10/6/1315
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Biomedicines. 10 (6): 1315-
    Referencia de l'ítem segons les normes APA: Bertran, Laia; Eigbefoh-Addeh, Ailende; Portillo-Carrasquer, Marta; Barrientos-Riosalido, Andrea; Binetti, Jessica; Aguilar, Carmen; Chicote, Javier U (2022). Identification of the Potential Molecular Mechanisms Linking RUNX1 Activity with Nonalcoholic Fatty Liver Disease, by Means of Systems Biology. Biomedicines, 10(6), 1315-. DOI: 10.3390/biomedicines10061315
    DOI del artículo: 10.3390/biomedicines10061315
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Biochemistry, Genetics and Molecular Biology (Miscellaneous),Medicine (Miscellaneous),Medicine, Research & Experimental,Pharmacology & Pharmacy
    Systems biology
    Runx1
    Protein-kinase-c
    Nash
    Nafld
    Metabolism
    systems biology
    reference database
    pathway
    nf-kappa-b
    nash
    nafld
    metabolism
    insulin-resistance
    growth-factor
    gene
    cell apoptosis
    alpha expression
    activation
    Pharmacology & pharmacy
    Medicine, research & experimental
    Medicine (miscellaneous)
    General biochemistry,genetics and molecular biology
    Ciencias sociales
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Biochemistry & molecular biology
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