Autor según el artículo: Martinez, Maria Angeles; Marques, Montse; Salas-Huetos, Albert; Babio, Nancy; Domingo, Jose L; Salas-Salvado, Jordi
Departamento: Ciències Mèdiques Bàsiques; Enginyeria Electrònica, Elèctrica i Automàtica; Bioquímica i Biotecnologia
Autor/es de la URV: Babio Sánchez, Nancy Elvira / Domingo Roig, José Luis / Marquès Bueno, Montserrat / Martínez Rodríguez, María Ángeles / Salas Huetos, Albert / Salas Salvadó, Jorge
Palabras clave: Spermatozoa; Sperm quality; Semen; Reproductive disorders; Pregnancy; Male fertility; Male; Humans; Fertility; Female; Endocrine disruptors; Endocrine disrupting chemicals; 2,4,5,2',4',5'-hexachlorobiphenyl
Resumen: The incidence of infertility currently affects about 15% of the world's population. Male factors are estimated to be responsible for up to 40-50% of these cases. While the cause of these reproductive disorders is still unclear, the exposure to a family of ubiquitous compounds in our daily life, named endocrine disrupting chemicals (EDCs) could be involved. This paper was aimed at performing a systematic review and meta-analysis of population studies exploring whether human male exposure to EDCs affects male fertility. Clinical and observational studies assessing the exposure to EDCs along with sperm quality, the most common reproductive disorders, sperm DNA damage, sperm oxidative stress, fertilization rate, implantation rate, clinical pregnancy rate, live birth rate, and miscarriage rate were included. The quality assessment tool from the NHLBI-NIH was used to assure that studies met standardized quality criteria. Sensitivity analysis and heterogeneity among studies was assessed. Overall, the 32 selected articles, including 7825 individuals in the systematic review, explored 12 families of EDCs. The results revealed a high heterogeneity among studies in relation to the association between exposure to EDCs and the endpoints analyzed. Meta-analyses were performed with data from 7 articles including 479 individuals, 4 articles assessing the association between BPA in urine and sperm quality, and 3 articles evaluating PCB153 in serum and sperm quality. In the meta-analysis, we identified an unpredicted significant positive association between PCB153 exposure and sperm concentration. However, it would not be clinically relevant. No positive or inverse associations were found neither for BPA, nor for PCB153 and the rest of sperm parameters analyzed. The high disparity between studies made difficult to draw conclusions on the potential harmful effects of EDCs on male fertility. Consequently, to delineate the potential relationship that EDCs can have on male fertility, an important condition stressing the health system, further investigations are required.Copyright © 2022. Published by Elsevier Inc.
Áreas temáticas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Public, environmental & occupational health; Public health, environmental and occupational health; Psicología; Planejamento urbano e regional / demografia; Odontología; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Geociências; General medicine; General environmental science; Farmacia; Environmental sciences; Environmental science (miscellaneous); Environmental science (all); Ensino; Engenharias iii; Engenharias ii; Engenharias i; Enfermagem; Educação física; Direito; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Biochemistry; Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: albert.salas@urv.cat; montserrat.marques@urv.cat; mangeles.martinez@urv.cat; joseluis.domingo@urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat
Fecha de alta del registro: 2025-03-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0013935122022691?via%3Dihub
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Environmental Research. 217 114942-114942
Referencia de l'ítem segons les normes APA: Martinez, Maria Angeles; Marques, Montse; Salas-Huetos, Albert; Babio, Nancy; Domingo, Jose L; Salas-Salvado, Jordi (2023). Lack of association between endocrine disrupting chemicals and male fertility: A systematic review and meta-analysis. Environmental Research, 217(), 114942-114942. DOI: 10.1016/j.envres.2022.114942
DOI del artículo: 10.1016/j.envres.2022.114942
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV