Articles producció científica> Enginyeria Química

In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario

  • Datos identificativos

    Identificador: imarina:9287011
    Handle: http://hdl.handle.net/20.500.11797/imarina9287011
  • Autores:

    Esplugas R
    Linares V
    Bellés M
    Domingo JL
    Schuhmacher M
  • Otros:

    Autor según el artículo: Esplugas R; Linares V; Bellés M; Domingo JL; Schuhmacher M
    Departamento: Enginyeria Química Ciències Mèdiques Bàsiques
    Autor/es de la URV: Bellés Mateu, Montserrat / Domingo Roig, José Luis / Esplugas Borràs, Roser / Linares Vidal, M. Victoria / Schuhmacher Ansuategui, Marta
    Palabras clave: Tris(1 Triphenyl phosphate (tphp) In vitro neurotoxicity Flame retardant (fr) Bis(2-ethylhexyl)tetrabromophthalate (beh-tebp) 3dichloro-2-propyl) phosphate (tdcpp) 3-dichloro-2-propyl)phosphate (tdcpp) 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (eh-tbb)
    Resumen: Since 2004, some legacy flame retardants (FRs) were restricted or removed from the European markets due to their concern on human health. Both organophosphorus FRs (OPFRs) and novel brominated FRs (NBFRs) have replaced them because they are presumably safer and less persistent emerging FRs (EFRs) and their exposure is currently occurring in indoor environments at high levels. Little is known about the neurotoxic potential risk of these EFRs in humans. The present study was aimed at assessing the acute neurotoxicity potential of Tris(1, 3dichloro-2-propyl) phosphate (TDCPP), triphenyl phosphate (TPhP), Bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) on human neuroblastoma cells (SH-SY5Y). SH-SY5Y were exposed to these EFRs at low concentrations -ranging 2.5-20 μM. during 2-24 h. We investigated viability, mitochondrial function, oxidative stress, inflammatory response, as well as neural plasticity and development. The results have demonstrated that selected EFRs (TDCPP, TPhP, EH-TBB and BEH-TBP) did not impair neural function on SH-SY5Y as acute response. To the best of our knowledge, this has been the first study focused on evaluating the neural affection of TPhP on SH-SY5Y cells and of EH-TBB and BEH-TBP on neural cells. We also assessed for the first time almost all endpoints after FR exposure on neural cell lines.Copyright © 2022. Published by Elsevier Ltd.
    Áreas temáticas: Zootecnia / recursos pesqueiros Toxicology Química Odontología Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: marta.schuhmacher@urv.cat montserrat.belles@urv.cat mvictoria.linares@urv.cat joseluis.domingo@urv.cat
    Identificador del autor: 0000-0003-4381-2490 0000-0002-9282-2989 0000-0003-4170-4197 0000-0001-6647-9470
    Fecha de alta del registro: 2023-02-23
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0887233322002211?via%3Dihub
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Toxicology In Vitro. 87 105523-105523
    Referencia de l'ítem segons les normes APA: Esplugas R; Linares V; Bellés M; Domingo JL; Schuhmacher M (2023). In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario. Toxicology In Vitro, 87(), 105523-105523. DOI: 10.1016/j.tiv.2022.105523
    DOI del artículo: 10.1016/j.tiv.2022.105523
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Medicine (Miscellaneous),Toxicology
    Tris(1
    Triphenyl phosphate (tphp)
    In vitro neurotoxicity
    Flame retardant (fr)
    Bis(2-ethylhexyl)tetrabromophthalate (beh-tebp)
    3dichloro-2-propyl) phosphate (tdcpp)
    3-dichloro-2-propyl)phosphate (tdcpp)
    2-ethylhexyl-2,3,4,5-tetrabromobenzoate (eh-tbb)
    Zootecnia / recursos pesqueiros
    Toxicology
    Química
    Odontología
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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