Autor según el artículo: Tomas, Josep; Lanuza, Maria A; Santafe, Manel M; Cilleros-Mane, Victor; Just-Borras, Laia; Balanya-Segura, Marta; Polishchuk, Aleksandra; Nadal, Laura; Tomas, Marta; Garcia, Neus
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Balanya Segura, Marta / Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Just Borràs, Laia / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / POLISHCHUK, ALEKSANDRA / Santafé Martínez, Manuel / Tomás Ferré, José Maria / Tomas Marginet, Marta
Palabras clave: Serine kinases Receptors, muscarinic Protein-kinase-c Postnatal synapse elimination Neuromuscular junction Muscarinic acetylcholine receptors Mammals Calcium channels Axons Axonal competition Animals Acetylcholine release Acetylcholine synapse elimination skeletal-muscle serine kinases postnatal-development polyneuronal innervation perisynaptic schwann-cells neurotransmitter release muscarinic acetylcholine receptors modulate transmitter release calcium-channels calcium channels axonal competition acetylcholine-release acetylcholine release
Resumen: In recent years, we have studied by immunohistochemistry, intracellular recording, and western blotting the role of the muscarinic acetylcholine receptors (mAChRs; M1, M2, and M4 subtypes) in the mammalian neuromuscular junction (NMJ) during development and in the adult. Here, we evaluate our published data to emphasize the mAChRs’ relevance in developmental synaptic elimination and their crosstalk with other metabotropic receptors, downstream kinases, and voltage-gated calcium channels (VGCCs). The presence of mAChRs in the presynaptic membrane of motor nerve terminals allows an autocrine mechanism in which the secreted acetylcholine influences the cell itself in feedback. mAChR subtypes are coupled to different downstream pathways, so their feedback can move in a broad range between positive and negative. Moreover, mAChRs allow direct activity-dependent interaction through ACh release between the multiple competing axons during development. Additional regulation from pre- and postsynaptic sites (including neurotrophic retrograde control), the agonistic and antagonistic contributions of adenosine receptors (AR; A1 and A2A), and the tropomyosin-related kinase B receptor (TrkB) cooperate with mAChRs in the axonal competitive interactions which lead to supernumerary synapse elimination that achieves the optimized monoinnervation of musculoskeletal cells. The metabotropic receptor-driven balance between downstream PKA and PKC activities, coupled to developmentally regulated VGCC, explains much of how nerve terminals with different activities finally progress to their withdrawal or strengthening.
Áreas temáticas: Saúde coletiva Química Odontología Nutrição Neurosciences Neuroscience (miscellaneous) Neurology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias iv Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Cellular and molecular neuroscience Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: marta.balanya@urv.cat aleksandra.polishchuk@urv.cat laia.just@urv.cat marta.tomas@urv.cat aleksandra.polishchuk@urv.cat marta.balanya@urv.cat victor.cilleros@alumni.urv.cat josepmaria.tomas@urv.cat laia.just@urv.cat mariaangel.lanuza@urv.cat manuel.santafe@urv.cat
Identificador del autor: 0000-0003-0983-4944 0000-0001-6445-1538 0000-0003-0473-3730 0000-0002-4151-1697 0000-0001-6445-1538 0000-0003-0983-4944 0000-0001-5690-9932 0000-0002-0406-0006 0000-0003-0473-3730 0000-0003-4795-4103 0000-0002-5462-5108
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://link.springer.com/article/10.1007/s12035-022-03154-1
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Molecular Neurobiology. 60 (3): 1580-1593
Referencia de l'ítem segons les normes APA: Tomas, Josep; Lanuza, Maria A; Santafe, Manel M; Cilleros-Mane, Victor; Just-Borras, Laia; Balanya-Segura, Marta; Polishchuk, Aleksandra; Nadal, Laura (2023). Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular Junction. Molecular Neurobiology, 60(3), 1580-1593. DOI: 10.1007/s12035-022-03154-1
DOI del artículo: 10.1007/s12035-022-03154-1
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications