Autor según el artículo: Klid, S; Maymó-Masip, E; Algaba-Chueca, F; Ballesteros, M; Inglès-Puig, M; Guarque, A; Madeira, A; Jareño, C; Vendrell, J; Fernández-Veledo, S; Megía, A
Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: Ballesteros Pérez, Monica / Fernandez Veledo, Sonia / Guarque Rus, Albert / Klid Klid, Sergiy / Maymo Masip, Elsa / Megía Colet, Ana / Vendrell Ortega, Juan José
Palabras clave: Placental endothelial lipase Lipid metabolism Gestational diabetes Fetal growth Angptl protein 8 pregnancy mellitus maternal obesity lipoprotein-lipase lipid-metabolism lipid metabolism improves fetal growth expression dysregulation angptl
Resumen: Dyslipidemia in gestational diabetes has been associated with worse perinatal outcomes. The ANGPTL3-4-8 axis regulates lipid metabolism, especially in the transition from fasting to feeding. In this study, we evaluated the response of ANGPTL3, 4, and 8 after the intake of a mixed meal in women with normal glucose tolerance and gestational diabetes, and we assessed their gene expressions in different placental locations. Regarding the circulating levels of ANGPTL3, 4, and 8, we observed an absence of ANGPTL4 response after the intake of the meal in the GDM group compared to its presence in the control group. At the placental level, we observed a glucose tolerance-dependent expression pattern of ANGPTL3 between the two placental sides. When we compared the GDM pregnancies with the control pregnancies, a downregulation of the maternal side ANGPTL3 expression was observed. This suggests a dysregulation of the ANGPTL3–4–8 axis in GDM, both at the circulating level after ingestion and at the level of placental expression. Furthermore, we discerned that the expressions of ANGPTL3, 4, and 8 were related to birth weight and placental weight in the GDM group, but not in the control group, which suggests that they may play a role in regulating the transplacental passage of nutrients.
Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: sonia.fernandez@urv.cat albert.guarque@urv.cat elsa.maymo@urv.cat monica.ballesteros@urv.cat sergiy.klidk@estudiants.urv.cat sergiy.klidk@estudiants.urv.cat ana.megia@urv.cat juanjose.vendrell@urv.cat
Identificador del autor: 0000-0003-2906-3788 0000-0002-9133-3120 0000-0002-5101-9452 0000-0002-6994-6115
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/1422-0067/24/3/2486
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 24 (3): 2486-
Referencia de l'ítem segons les normes APA: Klid, S; Maymó-Masip, E; Algaba-Chueca, F; Ballesteros, M; Inglès-Puig, M; Guarque, A; Madeira, A; Jareño, C; Vendrell, J; Fernández-Veledo, S; Megía, (2023). The ANGPTL3-4-8 Axis in Normal Gestation and in Gestational Diabetes, and Its Potential Involvement in Fetal Growth. International Journal Of Molecular Sciences, 24(3), 2486-. DOI: 10.3390/ijms24032486
DOI del artículo: 10.3390/ijms24032486
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications