Autor según el artículo: Barrientos-Riosalido, Andrea; Real, Monica; Bertran, Laia; Aguilar, Carmen; Martinez, Salome; Parada, David; Vives, Margarita; Sabench, Fatima; Riesco, David; Castillo, Daniel Del; Richart, Cristobal; Auguet, Teresa
Departamento: Medicina i Cirurgia
Autor/es de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Barrientos Riosalido, Andrea / Bertran Ramos, Laia / Del Castillo Déjardin, Daniel / Martínez González, María Salomé / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima / Vives Espelta, Margarida
Palabras clave: Rna, messenger Obesity Nonalcoholic steatohepatitis Non-alcoholic fatty liver disease Nafld Liver Lipid metabolism Humans Female Autophagy-related protein 7 Autophagy Atg7 protein, human Atg7
Resumen: The autophagy gene ATG7 has been shown to be essential for the induction of autophagy, a process that used to be suppressed in nonalcoholic fatty liver disease (NAFLD). However, the specific role of ATG7 in NAFLD remains unclear. The aim of this study was to analyze hepatic ATG7 mRNA and ATG7 protein expression regarding obesity-associated NAFLD. Patients included women classified into normal weight (NW, n = 6) and morbid obesity (MO, n = 72). The second group was subclassified into normal liver (NL, n = 11), simple steatosis (SS, n= 29), and nonalcoholic steatohepatitis (NASH, n = 32). mRNA expression was analyzed by RT–qPCR and protein expression was evaluated by Western blotting. Our results showed that NASH patients presented higher ATG7 mRNA and ATG7 protein levels. ATG7 mRNA expression was increased in NASH compared with SS, while ATG7 protein abundance was enhanced in NASH compared with NL. ATG7 mRNA correlated negatively with the expression of some hepatic lipid metabolism-related genes and positively with endocannabinoid receptors, adiponectin hepatic expression, and omentin levels. These results suggest that ATG7-mediated autophagy may play an important role in the pathogenesis of NAFLD, especially in NASH, perhaps playing a possible protective role. However, this is a preliminary study that needs to be further studied.
Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: andrea.barrientos@urv.cat andrea.barrientos@urv.cat margarida.vives@urv.cat mariasalome.martinez@urv.cat danieldel.castillo@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Identificador del autor: 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/1422-0067/24/2/1324
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 24 (2): 1324-
Referencia de l'ítem segons les normes APA: Barrientos-Riosalido, Andrea; Real, Monica; Bertran, Laia; Aguilar, Carmen; Martinez, Salome; Parada, David; Vives, Margarita; Sabench, Fatima; Riesco (2023). Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity. International Journal Of Molecular Sciences, 24(2), 1324-. DOI: 10.3390/ijms24021324
DOI del artículo: 10.3390/ijms24021324
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications