Articles producció científica> Bioquímica i Biotecnologia

Photoperiod Conditions Modulate Serum Oxylipins Levels in Healthy and Obese Rats: Impact of Proanthocyanidins and Gut Microbiota

  • Datos identificativos

    Identificador: imarina:9291922
    Autores:
    Arreaza-Gil, VAvila-Román, JEscobar-Martínez, IMuguerza, BSuárez, MArola-Arnal, ATorres-Fuentes, C
    Resumen:
    Seasonal rhythms are emerging as a key factor influencing gut microbiota and bioactive compounds functionality as well as several physiological processes such as inflammation. In this regard, their impact on the modulation of oxylipins (OXLs), which are important lipid mediators of inflammatory processes, has not been investigated yet. Hence, we aimed to investigate the effects of photoperiods on OXLs metabolites in healthy and obesogenic conditions. Moreover, we evaluated if the impact of proanthocyanidins and gut microbiota on OXLs metabolism is influenced by photoperiod in obesity. To this purpose, Fischer 344 rats were housed under different photoperiod conditions (L6: 6 h light, L12: 12 h light or L18:18 h light) and fed either a standard chow diet (STD) or a cafeteria diet (CAF) for 9 weeks. During the last 4 weeks, obese rats were daily administered with an antibiotic cocktail (ABX), an oral dose of a grape seed proanthocyanidin extract (GSPE), or with their combination. CAF feeding and ABX treatment affected OXLs in a photoperiod dependent-manner. GSPE significantly altered prostaglandin E2 (PGE2) levels, only under L6 and mitigated ABX-mediated effects only under L18. In conclusion, photoperiods affect OXLs levels influenced by gut microbiota. This is the first time that the effects of photoperiod on OXLs metabolites have been demonstrated.
  • Otros:

    Autor según el artículo: Arreaza-Gil, V; Avila-Román, J; Escobar-Martínez, I; Muguerza, B; Suárez, M; Arola-Arnal, A; Torres-Fuentes, C
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Arola Arnal, Anna / Arreaza Gil, Verónica / Ávila Román, Francisco Javier / Escobar Martínez, Ivan / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel / Torres Fuentes, Cristina
    Palabras clave: Seasonal-variation Resolvins Obesity Gspe Cafeteria diet Biological rhythms weight resolvins profiles obesity metabolism mediators inflammation gspe clock cafeteria diet acid
    Resumen: Seasonal rhythms are emerging as a key factor influencing gut microbiota and bioactive compounds functionality as well as several physiological processes such as inflammation. In this regard, their impact on the modulation of oxylipins (OXLs), which are important lipid mediators of inflammatory processes, has not been investigated yet. Hence, we aimed to investigate the effects of photoperiods on OXLs metabolites in healthy and obesogenic conditions. Moreover, we evaluated if the impact of proanthocyanidins and gut microbiota on OXLs metabolism is influenced by photoperiod in obesity. To this purpose, Fischer 344 rats were housed under different photoperiod conditions (L6: 6 h light, L12: 12 h light or L18:18 h light) and fed either a standard chow diet (STD) or a cafeteria diet (CAF) for 9 weeks. During the last 4 weeks, obese rats were daily administered with an antibiotic cocktail (ABX), an oral dose of a grape seed proanthocyanidin extract (GSPE), or with their combination. CAF feeding and ABX treatment affected OXLs in a photoperiod dependent-manner. GSPE significantly altered prostaglandin E2 (PGE2) levels, only under L6 and mitigated ABX-mediated effects only under L18. In conclusion, photoperiods affect OXLs levels influenced by gut microbiota. This is the first time that the effects of photoperiod on OXLs metabolites have been demonstrated.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: franciscojavier.avila@urv.cat ivan.escobar@estudiants.urv.cat veronica.arreaza@urv.cat veronica.arreaza@urv.cat veronica.arreaza@urv.cat manuel.suarez@urv.cat anna.arola@urv.cat begona.muguerza@urv.cat cristina.torres@urv.cat
    Identificador del autor: 0000-0001-9766-8178 0000-0002-8301-2095 0000-0002-8301-2095 0000-0002-8301-2095 0000-0003-0122-8253 0000-0001-6529-1345 0000-0001-7384-8588 0000-0002-2917-6910
    Fecha de alta del registro: 2024-09-21
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2072-6643/15/3/707
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nutrients. 15 (3):
    Referencia de l'ítem segons les normes APA: Arreaza-Gil, V; Avila-Román, J; Escobar-Martínez, I; Muguerza, B; Suárez, M; Arola-Arnal, A; Torres-Fuentes, C (2023). Photoperiod Conditions Modulate Serum Oxylipins Levels in Healthy and Obese Rats: Impact of Proanthocyanidins and Gut Microbiota. Nutrients, 15(3), -. DOI: 10.3390/nu15030707
    DOI del artículo: 10.3390/nu15030707
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Seasonal-variation
    Resolvins
    Obesity
    Gspe
    Cafeteria diet
    Biological rhythms
    weight
    resolvins
    profiles
    obesity
    metabolism
    mediators
    inflammation
    gspe
    clock
    cafeteria diet
    acid
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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