Articles producció científica> Química Física i Inorgànica

Microfluidic Device for the Manipulation of Microparticles for Flow Cytometry Application

  • Datos identificativos

    Identificador: imarina:9320438
    Autores:
    Attard, MCoral, DPedrol, EAguiló, MDíaz, FMateos, X
    Resumen:
    This work produces a unique microfluidic device that acts as a “lab on a chip,” conducting separation, mixing, and concentration of microparticles similar to that required by cell sorting flow cytometry applications. The passive two-dimensional device shows to be successful at separating polystyrene (PS) beads between 5 and 20 µm in diameter, mixing them with an external media, and concentrating them by 250% continuously with minimal sample preparation, while still being inexpensive, and effective. By implementing the microfluidic device, the processing steps are done within seconds due to its high throughput of 2 mL min−1, wherein different hydrodynamic phenomena such as Dean's forces, inertial lift forces, and enhanced diffusion are taken advantage of.
  • Otros:

    Autor según el artículo: Attard, M; Coral, D; Pedrol, E; Aguiló, M; Díaz, F; Mateos, X
    Departamento: Química Física i Inorgànica
    Autor/es de la URV: Aguiló Díaz, Magdalena / Díaz González, Francisco Manuel / Mateos Ferré, Xavier
    Palabras clave: Microparticle manipulation Microfluidic devices Labs-on-a-chip Flow cytometry Circulating tumor-cells Cell sorting separation particle mixer microparticle manipulation micromixer microfluidic devices labs-on-a-chip flow cytometry channel cancer
    Resumen: This work produces a unique microfluidic device that acts as a “lab on a chip,” conducting separation, mixing, and concentration of microparticles similar to that required by cell sorting flow cytometry applications. The passive two-dimensional device shows to be successful at separating polystyrene (PS) beads between 5 and 20 µm in diameter, mixing them with an external media, and concentrating them by 250% continuously with minimal sample preparation, while still being inexpensive, and effective. By implementing the microfluidic device, the processing steps are done within seconds due to its high throughput of 2 mL min−1, wherein different hydrodynamic phenomena such as Dean's forces, inertial lift forces, and enhanced diffusion are taken advantage of.
    Áreas temáticas: Química Nanoscience & nanotechnology Medicina ii Medicina i Materials science, multidisciplinary Materials science, characterization & testing Materials science (miscellaneous) Materials science (all) Materiais General materials science General chemistry Engineering, chemical Engenharias iv Engenharias ii Condensed matter physics Chemistry, physical Chemistry (miscellaneous) Chemistry (all) Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: f.diaz@urv.cat magdalena.aguilo@urv.cat xavier.mateos@urv.cat
    Identificador del autor: 0000-0003-4581-4967 0000-0001-6130-9579 0000-0003-1940-1990
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1002/ppsc.202300038
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Particle & Particle Systems Characterization. 40 (9):
    Referencia de l'ítem segons les normes APA: Attard, M; Coral, D; Pedrol, E; Aguiló, M; Díaz, F; Mateos, X (2023). Microfluidic Device for the Manipulation of Microparticles for Flow Cytometry Application. Particle & Particle Systems Characterization, 40(9), -. DOI: 10.1002/ppsc.202300038
    DOI del artículo: 10.1002/ppsc.202300038
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemistry (Miscellaneous),Chemistry, Physical,Condensed Matter Physics,Engineering, Chemical,Materials Science (Miscellaneous),Materials Science, Characterization & Testing,Materials Science, Multidisciplinary,Nanoscience & Nanotechnology
    Microparticle manipulation
    Microfluidic devices
    Labs-on-a-chip
    Flow cytometry
    Circulating tumor-cells
    Cell sorting
    separation
    particle
    mixer
    microparticle manipulation
    micromixer
    microfluidic devices
    labs-on-a-chip
    flow cytometry
    channel
    cancer
    Química
    Nanoscience & nanotechnology
    Medicina ii
    Medicina i
    Materials science, multidisciplinary
    Materials science, characterization & testing
    Materials science (miscellaneous)
    Materials science (all)
    Materiais
    General materials science
    General chemistry
    Engineering, chemical
    Engenharias iv
    Engenharias ii
    Condensed matter physics
    Chemistry, physical
    Chemistry (miscellaneous)
    Chemistry (all)
    Astronomia / física
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