Autor según el artículo: Novau-Ferre, Nil; Rojas, Melina; Gutierrez-Tordera, Laia; Arcelin, Pierre; Folch, Jaume; Papandreou, Christopher; Bullo, Monica
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Bulló Bonet, Mònica / Folch Lopez, Jaume / GUTIERREZ TORDERA, LAIA / Novau Ferré, Nil / Rojas Criollo, Melina Isabella
Palabras clave: Wrap53 Tert Telomere shortening Telomere length Telomere Telomerase complex components Telomerase Oxidative stress Lipoprotein subclasses Humans Hdl-cholesterol Cellular senescence wrap53 tert telomere length telomerase complex components risk population men hypertension disease
Resumen: Telomere length (TL) is a well-known marker of age-related diseases. Oxidative stress and inflammation increase the rate of telomere shortening, triggering cellular senescence. Although lipoproteins could have anti-inflammatory and proinflammatory functional properties, the relationship between lipoprotein particles with TL and telomerase activity-related genes has not been investigated much. In this study, we assessed the associations of lipoprotein subfractions with telomere length, TERT, and WRAP53 expression in a total of 54 pre-diabetic subjects from the EPIRDEM study. We regressed TL, TERT, and WRAP53 on 12 lipoprotein subclasses, employing a Gaussian linear regression method with Lasso penalty to determine a lipoprotein profile associated with telomere-related parameters. The covariates included age, sex, body mass index (BMI), dyslipidemia, statin consumption, and physical activity leisure time. We identified a lipoprotein profile composed of four lipoprotein subfractions associated with TL (Pearson r = 0.347, p-value = 0.010), two lipoprotein subfractions associated with TERT expression (Pearson r = 0.316, p-value = 0.020), and five lipoprotein subfractions associated with WRAP53 expression (Pearson r = 0.379, p-value =0.005). After adjusting for known confounding factors, most lipoprotein profiles maintained the association with TL, TERT, and WRAP53. Overall, medium and small-sized HDL particles were associated with shorter telomeres and lower expression of TERT and WRAP53. Large HDL particles were associated with longer telomere and lower expression of WRAP53, but not with TERT. Our results suggest that the lipoprotein profiles are associated with telomere length, TERT, and WRAP53 expression and should be considered when assessing the risk of chronic diseases.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: nil.novau@urv.cat melina.rojas@estudiants.urv.cat laia.gutierrez@urv.cat monica.bullo@urv.cat jaume.folch@urv.cat
Identificador del autor: 0000-0002-0218-7046 0000-0002-5051-8858
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/15/11/2624
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 15 (11): 2624-
Referencia de l'ítem segons les normes APA: Novau-Ferre, Nil; Rojas, Melina; Gutierrez-Tordera, Laia; Arcelin, Pierre; Folch, Jaume; Papandreou, Christopher; Bullo, Monica (2023). Lipoprotein Particle Profiles Associated with Telomere Length and Telomerase Complex Components. Nutrients, 15(11), 2624-. DOI: 10.3390/nu15112624
DOI del artículo: 10.3390/nu15112624
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications