Articles producció científica> Medicina i Cirurgia

TCA cycle metabolites associated with adverse outcomes after acute coronary syndrome: mediating effect of renal function

  • Datos identificativos

    Identificador: imarina:9325770
    Autores:
    Sanchez-Gimenez, RaulPeiro, Oscar MBonet, GilCarrasquer, AnnaFragkiadakis, George ABullo, MonicaPapandreou, ChristopherBardaji, Alfredo
    Resumen:
    Aims: To examine relationships of tricarboxylic acid (TCA) cycle metabolites with risk of cardiovascular events and mortality after acute coronary syndrome (ACS), and evaluate the mediating role of renal function in these associations. Methods: This is a prospective study performed among 309 ACS patients who were followed for a mean of 6.7 years. During this period 131 patients developed major adverse cardiovascular events (MACE), defined as the composite of myocardial infarction, hospitalization for heart failure, and all-cause mortality, and 90 deaths were recorded. Plasma concentrations of citrate, aconitate, isocitrate, succinate, malate, fumarate, α-ketoglutarate and d/l-2-hydroxyglutarate were quantified using LC-tandem MS. Multivariable Cox regression models were used to estimate hazard ratios, and a counterfactual-based mediation analysis was performed to test the mediating role of estimated glomerular filtration rate (eGFR). Results: After adjustment for traditional cardiovascular risk factors and medications, positive associations were found between isocitrate and MACE (HR per 1 SD, 1.25; 95% CI: 1.03, 1.50), and between aconitate, isocitrate, d/l-2-hydroxyglutarate and all-cause mortality (HR per 1 SD, 1.41; 95% CI: 1.07, 1.84; 1.58; 95% CI: 1.23, 2.02; 1.38; 95% CI: 1.14, 1.68). However, these associations were no longer significant after additional adjustment for eGFR. Mediation analyses demonstrated that eGFR is a strong mediator of these associations. Conclusion: These findings underscore the importance of TCA metabolites and renal function as conjunctive targets in the prevention of ACS complications.
  • Otros:

    Autor según el artículo: Sanchez-Gimenez, Raul; Peiro, Oscar M; Bonet, Gil; Carrasquer, Anna; Fragkiadakis, George A; Bullo, Monica; Papandreou, Christopher; Bardaji, Alfredo
    Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia
    Autor/es de la URV: Bardají Ruiz, Alfredo / Bonet Pineda, Gil / Bulló Bonet, Mònica / Carrasquer Cucarella, Ana Maria / Peiró Ibáñez, Óscar Manuel / Sánchez Giménez, Raúl
    Palabras clave: Tricarboxylic acid cycle Mortality Metabolomics Mass spectrometry Major adverse cardiovascular events Acute coronary syndrome
    Resumen: Aims: To examine relationships of tricarboxylic acid (TCA) cycle metabolites with risk of cardiovascular events and mortality after acute coronary syndrome (ACS), and evaluate the mediating role of renal function in these associations. Methods: This is a prospective study performed among 309 ACS patients who were followed for a mean of 6.7 years. During this period 131 patients developed major adverse cardiovascular events (MACE), defined as the composite of myocardial infarction, hospitalization for heart failure, and all-cause mortality, and 90 deaths were recorded. Plasma concentrations of citrate, aconitate, isocitrate, succinate, malate, fumarate, α-ketoglutarate and d/l-2-hydroxyglutarate were quantified using LC-tandem MS. Multivariable Cox regression models were used to estimate hazard ratios, and a counterfactual-based mediation analysis was performed to test the mediating role of estimated glomerular filtration rate (eGFR). Results: After adjustment for traditional cardiovascular risk factors and medications, positive associations were found between isocitrate and MACE (HR per 1 SD, 1.25; 95% CI: 1.03, 1.50), and between aconitate, isocitrate, d/l-2-hydroxyglutarate and all-cause mortality (HR per 1 SD, 1.41; 95% CI: 1.07, 1.84; 1.58; 95% CI: 1.23, 2.02; 1.38; 95% CI: 1.14, 1.68). However, these associations were no longer significant after additional adjustment for eGFR. Mediation analyses demonstrated that eGFR is a strong mediator of these associations. Conclusion: These findings underscore the importance of TCA metabolites and renal function as conjunctive targets in the prevention of ACS complications.
    Áreas temáticas: Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: gil.bonet@urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat raul.sanchez@estudiants.urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat monica.bullo@urv.cat alfredo.bardaji@urv.cat
    Identificador del autor: 0000-0002-0218-7046 0000-0003-1900-6974
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fcvm.2023.1157325/full
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Front Cardiovasc Med. 10 1157325-
    Referencia de l'ítem segons les normes APA: Sanchez-Gimenez, Raul; Peiro, Oscar M; Bonet, Gil; Carrasquer, Anna; Fragkiadakis, George A; Bullo, Monica; Papandreou, Christopher; Bardaji, Alfredo (2023). TCA cycle metabolites associated with adverse outcomes after acute coronary syndrome: mediating effect of renal function. Front Cardiovasc Med, 10(), 1157325-. DOI: 10.3389/fcvm.2023.1157325
    DOI del artículo: 10.3389/fcvm.2023.1157325
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Tricarboxylic acid cycle
    Mortality
    Metabolomics
    Mass spectrometry
    Major adverse cardiovascular events
    Acute coronary syndrome
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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