Articles producció científica> Medicina i Cirurgia

Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients

  • Datos identificativos

    Identificador: imarina:9326329
    Autores:
    Lejeune, MReverte, LGallardo, NSauras, EBosch, RMata, DRoso, APetit, APeg, VRiu, FGarcia-Fontgivell, JRelea, FVieites, Bde la Cruz-merino, LArenas, MRodriguez, VGalera, JKorzynska, APlancoulaine, BAlvaro, TLopez, C
    Resumen:
    Triple-negative breast cancer (TNBC) is particularly challenging due to the weak or absent response to therapeutics and its poor prognosis. The effectiveness of neoadjuvant chemotherapy (NAC) response is strongly influenced by changes in elements of the tumor microenvironment (TME). This work aimed to characterize the residual TME composition in 96 TNBC patients using immunohistochemistry and in situ hybridization techniques and evaluate its prognostic implications for partial responders vs. non-responders. Compared with non-responders, partial responders containing higher levels of CD83+ mature dendritic cells, FOXP3+ regulatory T cells, and IL-15 expression but lower CD138+ cell concentration exhibited better OS and RFS. However, along with tumor diameter and positive nodal status at diagnosis, matrix metalloproteinase-9 (MMP-9) expression in the residual TME was identified as an independent factor associated with the impaired response to NAC. This study yields new insights into the key components of the residual tumor bed, such as MMP-9, which is strictly associated with the lack of a pathological response to NAC. This knowledge might help early identification of TNBC patients less likely to respond to NAC and allow the establishment of new therapeutic targets.
  • Otros:

    Autor según el artículo: Lejeune, M; Reverte, L; Gallardo, N; Sauras, E; Bosch, R; Mata, D; Roso, A; Petit, A; Peg, V; Riu, F; Garcia-Fontgivell, J; Relea, F; Vieites, B; de la Cruz-merino, L; Arenas, M; Rodriguez, V; Galera, J; Korzynska, A; Plancoulaine, B; Alvaro, T; Lopez, C
    Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/es de la URV: Arenas Prat, Meritxell / Galera Ortega, Juana / Lejeune, Marylène Marie / Lopez Pablo, Carlos
    Palabras clave: Tumor microenvironment Triple-negative breast cancer Pathological response Neoadjuvant chemotherapy Biomarkers tumor microenvironment pathological response neoadjuvant chemotherapy biomarkers
    Resumen: Triple-negative breast cancer (TNBC) is particularly challenging due to the weak or absent response to therapeutics and its poor prognosis. The effectiveness of neoadjuvant chemotherapy (NAC) response is strongly influenced by changes in elements of the tumor microenvironment (TME). This work aimed to characterize the residual TME composition in 96 TNBC patients using immunohistochemistry and in situ hybridization techniques and evaluate its prognostic implications for partial responders vs. non-responders. Compared with non-responders, partial responders containing higher levels of CD83+ mature dendritic cells, FOXP3+ regulatory T cells, and IL-15 expression but lower CD138+ cell concentration exhibited better OS and RFS. However, along with tumor diameter and positive nodal status at diagnosis, matrix metalloproteinase-9 (MMP-9) expression in the residual TME was identified as an independent factor associated with the impaired response to NAC. This study yields new insights into the key components of the residual tumor bed, such as MMP-9, which is strictly associated with the lack of a pathological response to NAC. This knowledge might help early identification of TNBC patients less likely to respond to NAC and allow the establishment of new therapeutic targets.
    Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: juana.galera@urv.cat carlos.lopez@urv.cat marylenemarie.lejeune@urv.cat meritxell.arenas@urv.cat
    Identificador del autor: 0000-0003-1248-3065 0000-0001-8441-9404 0000-0003-0815-2570
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/1422-0067/24/14/11297
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 24 (14):
    Referencia de l'ítem segons les normes APA: Lejeune, M; Reverte, L; Gallardo, N; Sauras, E; Bosch, R; Mata, D; Roso, A; Petit, A; Peg, V; Riu, F; Garcia-Fontgivell, J; Relea, F; Vieites, B; de l (2023). Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients. International Journal Of Molecular Sciences, 24(14), -. DOI: 10.3390/ijms241411297
    DOI del artículo: 10.3390/ijms241411297
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Tumor microenvironment
    Triple-negative breast cancer
    Pathological response
    Neoadjuvant chemotherapy
    Biomarkers
    tumor microenvironment
    pathological response
    neoadjuvant chemotherapy
    biomarkers
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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