Articles producció científica> Bioquímica i Biotecnologia

Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

  • Datos identificativos

    Identificador: imarina:9332609
    Handle: https://hdl.handle.net/20.500.11797/imarina9332609
    Autores:
    Doímnguez-Lpóez, IGalkina, PParilli-Moser, IArancibia-Riveros, CMartínez-González, MASalas-Salvadó, JCorella, DMalcampo, MMartínez, JATojal-Sierra, LWärnberg, JVioque, JRomaguera, DLópez-Miranda, JEstruch, RTinahones, FJSantos-Lozano, JMSerra-Majem, LBueno-Cavanillas, ATur, JARubín-García, MPintó, XFernández-Aranda, FDelgado-Rodríguez, MBarabash-Bustelo, AVidal, JVázquez, CDaimiel, LRos, EToledo, EAtzeni, AAsensio, EMVera, NGarcia-Rios, ATorres-Collado, LPérez-Farinós, NZulet, MChaplin, ACasas, RMartín-Peláez, SVaquero-Luna, JGómez-Pérez, AMVázquez-Ruiz, ZShyam, SOrtega-Azorín, CTalens, NPeña-Orihuela, PJOncina-Canovas, ADiez-Espino, JBabio, NFitó, MLamuela-Raventós, RM
    Resumen:
    Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older population at high cardiovascular risk.A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid chromatography coupled to mass spectrometry is used to identify urinary MPM. Mediterranean diet (MedDiet) adherence is estimated with a 17-item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests. Multivariable-adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3-hydroxybenzoic acid, enterodiol glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests. Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini-Mental State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores.These results suggest that the MedDiet is linked to MPM associated with better cognitive performance in an older population.© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.

  • Otros:

    Autor según el artículo: Doímnguez-Lpóez, I; Galkina, P; Parilli-Moser, I; Arancibia-Riveros, C; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Malcampo, M; Martínez, JA; Tojal-Sierra, L; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Santos-Lozano, JM; Serra-Majem, L; Bueno-Cavanillas, A; Tur, JA; Rubín-García, M; Pintó, X; Fernández-Aranda, F; Delgado-Rodríguez, M; Barabash-Bustelo, A; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Toledo, E; Atzeni, A; Asensio, EM; Vera, N; Garcia-Rios, A; Torres-Collado, L; Pérez-Farinós, N; Zulet, M; Chaplin, A; Casas, R; Martín-Peláez, S; Vaquero-Luna, J; Gómez-Pérez, AM; Vázquez-Ruiz, Z; Shyam, S; Ortega-Azorín, C; Talens, N; Peña-Orihuela, PJ; Oncina-Canovas, A; Diez-Espino, J; Babio, N; Fitó, M; Lamuela-Raventós, RM
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
    Palabras clave: Predimed-plus Neurodegeneration Mini-mental state Mediterranean diet Cognition Bioactive compounds vanillic acid validity predimed-plus polyphenol older neurodegeneration mediterranean diet lignans gut microbiota cognition biomarker alzheimers-disease
    Resumen: Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older population at high cardiovascular risk.A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid chromatography coupled to mass spectrometry is used to identify urinary MPM. Mediterranean diet (MedDiet) adherence is estimated with a 17-item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests. Multivariable-adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3-hydroxybenzoic acid, enterodiol glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests. Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini-Mental State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores.These results suggest that the MedDiet is linked to MPM associated with better cognitive performance in an older population.© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
    Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: alessandro.atzeni@urv.cat alessandro.atzeni@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Identificador del autor: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0003-2700-7459 0000-0003-3527-5277
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 68 (2): e2300183-e2300183
    Referencia de l'ítem segons les normes APA: Doímnguez-Lpóez, I; Galkina, P; Parilli-Moser, I; Arancibia-Riveros, C; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Malcampo, M; Martínez, JA (2024). Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health. Molecular Nutrition & Food Research, 68(2), e2300183-e2300183. DOI: 10.1002/mnfr.202300183
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2024
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Biotechnology,Food Science,Food Science & Technology
    Predimed-plus
    Neurodegeneration
    Mini-mental state
    Mediterranean diet
    Cognition
    Bioactive compounds
    vanillic acid
    validity
    predimed-plus
    polyphenol
    older
    neurodegeneration
    mediterranean diet
    lignans
    gut microbiota
    cognition
    biomarker
    alzheimers-disease
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física

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