Autor según el artículo: Nguyen NP; Mohammadianpanah M; SunMyint A; Page BR; Vinh-Hung V; Gorobets O; Arenas M; Mazibuko T; Giap H; Vasileiou M; Dutheil F; Tuscano C; Karlsson UL; Dahbi Z; Natoli E; Li E; Kim L; Oboite J; Oboite E; Bose S; Vuong T
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Arenas Prat, Meritxell
Palabras clave: Cpi Locally advanced Older Radiotherapy Rectal cancer
Resumen: The standard of care for locally advanced rectal cancer is total neoadjuvant therapy followed by surgical resection. Current evidence suggests that selected patients may be able to delay or avoid surgery without affecting survival rates if they achieve a complete clinical response (CCR). However, for older cancer patients who are too frail for surgery or decline the surgical procedure, local recurrence may lead to a deterioration of patient quality of life. Thus, for clinicians, a treatment algorithm which is well tolerated and may improve CCR in older and frail patients with rectal cancer may improve the potential for prolonged remission and potential cure. Recently, immunotherapy with check point inhibitors (CPI) is a promising treatment in selected patients with high expression of program death ligands receptor 1 (PD- L1). Radiotherapy may enhance PD-L1 expression in rectal cancer and may improve response rate to immunotherapy. We propose an algorithm combining immunotherapy and radiotherapy for older patients with locally advanced rectal cancer who are too frail for surgery or who decline surgery.
Áreas temáticas: Biotecnología Cancer research Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Interdisciplinar Medicina i Medicina ii Oncology Saúde coletiva
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: meritxell.arenas@urv.cat
Identificador del autor: 0000-0003-0815-2570
Fecha de alta del registro: 2024-03-23
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1325610/full
Referencia al articulo segun fuente origial: Frontiers In Oncology. 14
Referencia de l'ítem segons les normes APA: Nguyen NP; Mohammadianpanah M; SunMyint A; Page BR; Vinh-Hung V; Gorobets O; Arenas M; Mazibuko T; Giap H; Vasileiou M; Dutheil F; Tuscano C; Karlsson (2024). Immunotherapy and radiotherapy for older patients with locally advanced rectal cancer unfit for surgery or decline surgery: a practical proposal by the International Geriatric Radiotherapy Group. Frontiers In Oncology, 14(), -. DOI: 10.3389/fonc.2024.1325610
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.3389/fonc.2024.1325610
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications