Autor según el artículo: Guerrini, C; Escribano, J; Ramírez, N; Vinaixa, M; Sunyer-Caldú, A; Gil-Solsona, R; Gago-Ferrero, P
Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/es de la URV: Ramírez González, Noelia / Vinaixa Crevillent, Maria
Palabras clave: Wide-scope screening Suspect screening analysis Suspect screening analysi Suspect Substances Non-targeted analysis Metabolites Human exposure High-resolution mass spectrometry Health Exposomics Environmental chemicals Early-life Current knowledge Contaminants Chemical exposome Challeng Biomarkers
Resumen: Exposure to organic compounds during early-life stages can disrupt human development and increase susceptibility to adverse health outcomes later in life. Despite evidence of these impacts, research has primarily focused on targeted analyses, missing the complex nature of early-life exposures. Comprehensive approaches are needed to better characterize these complex mixtures. Recent advances in high-resolution mass spectrometry and computational science have enabled the comprehensive analysis of numerous chemicals through wide-scope screening approaches, yet their application in early-life exposome studies is still limited. This review critically examines studies from the past decade using wide-scope screening to investigate the early-life chemical exposome, emphasizing organic compounds. It evaluates each step of the analytical workflow, including sample collection, preparation, analysis, and data processing, and concludes with recommendations for future research to improve understanding of the early-life chemical exposome and its health implications.
Áreas temáticas: Spectroscopy Química Medicina ii Interdisciplinar Farmacia Environmental chemistry Engenharias iv Engenharias iii Engenharias ii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Astronomia / física Analytical chemistry
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: maria.vinaixa@urv.cat
Identificador del autor: 0000-0001-9804-0171
Fecha de alta del registro: 2024-09-14
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0165993624003868
Referencia al articulo segun fuente origial: Trac-Trends In Analytical Chemistry. 180 117903-
Referencia de l'ítem segons les normes APA: Guerrini, C; Escribano, J; Ramírez, N; Vinaixa, M; Sunyer-Caldú, A; Gil-Solsona, R; Gago-Ferrero, P (2024). Early-life chemical exposome: Comprehensive strategies for wide-scope screening of organic compounds. Trac-Trends In Analytical Chemistry, 180(), 117903-. DOI: 10.1016/j.trac.2024.117903
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.trac.2024.117903
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV