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Data from: An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

  • Identification data

    Identifier: PC:4018
    Authors:
    Gamarra, Beatriz
    Abstract:
    Human culture, biology, and health were shaped dramatically by the onset of agriculture ~12,000 years before present (BP). This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared ‘predicted’ genetic contributions to height from paleogenomic data and ‘achieved’ adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (~38,000-2,400 BP). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of -3.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P=0.040) and -2.21 cm shorter relative to post-Neolithic individuals (P=0.068, with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation, for example with Neolithic individuals -2.82 cm shorter than expected on average relative to pre-Neolithic individuals (P=0.120). We also incorporated observations of paleopathological indicators of non-specific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory.
  • Others:

    Subject matter: Biologia
    Access rights: info:eu-repo/semantics/openAccess
    Researcher identifier: 0000-0003-3764-497X
    Published by (editorial): Universitat Rovira i Virgili (URV)
    Related publications: Marciniak, S., Bergey, C. M., Silva, A. M., Hałuszko, A., Furmanek, M., Veselka, B., Velemínský, P., Vercellotti, G., Wahl, J., Zariņa, G., Longhi, C., Kolář, J., Garrido-Pena, R., Flores-Fernández, R., Herrero-Corral, A. M., Simalcsik, A., Müller, W., Sheridan, A., Miliauskienė, Ž., … Perry, G. H. (2021). An integrative skeletal and paleogenomic analysis of prehistoric stature variation suggests relatively reduced health for early European farmers. https://doi.org/10.1101/2021.03.31.437881
    Abstract: Human culture, biology, and health were shaped dramatically by the onset of agriculture ~12,000 years before present (BP). This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared ‘predicted’ genetic contributions to height from paleogenomic data and ‘achieved’ adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (~38,000-2,400 BP). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of -3.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P=0.040) and -2.21 cm shorter relative to post-Neolithic individuals (P=0.068, with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation, for example with Neolithic individuals -2.82 cm shorter than expected on average relative to pre-Neolithic individuals (P=0.120). We also incorporated observations of paleopathological indicators of non-specific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory.
    Departament: Història i Història de l'Art
    DOI: 10.5061/dryad.b5mkkwhfp
    Document type: info:eu-repo/semantics/other
    Related publication's DOI: 10.1101/2021.03.31.437881
    Repository ingest date: 2022-03-30
    Author: Gamarra, Beatriz
    Keywords: Biological sciences
    Dataset publication year: 2022
    Dataset title: Data from: An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers