Gold catalysis: Total Synthesis of the Englerins and an Approach Towards Shisanwilsonene A

Tesis doctorals> Departament de Química

Gold catalysis: Total Synthesis of the Englerins and an Approach Towards Shisanwilsonene A

Dades identificatives

Identificador: TDX:1238

Handle: https://hdl.handle.net/20.500.11797/TDX1238

Autors:
Delpont, Nicolas

Resum:
Over the last years, our research group reported several methodologies dealing with the activation of alkynes using gold as a catalyst. One of the objectives of this Thesis was the development of a new catalytic system for the intramolecular [4+2] cycloaddition of aryl enynes. After screening of different ligands and several optimizations, up to 88% ee could be obtained by using a bulky chiral gold phosphite. The two other chapters of this Thesis are dealing with the synthesis of natural products involving a gold-catalyzed transformation as a key step in the synthesis. The total synthesis of (-)-englerins A and B is reported and a study towards the synthesis of Schisanwilsonene A is also described.
Altres:

Data: 2011-04-26
Departament/Institut: Departament de Química Analítica i Química Orgànica Universitat Rovira i Virgili.
Idioma: eng
Identificador: http://hdl.handle.net/10803/124043
Font: TDX (Tesis Doctorals en Xarxa)
Autor: Delpont, Nicolas
Director: Echavarren, Antonio M.
Format: application/pdf 285 p.
Editor: Universitat Rovira i Virgili
Paraula Clau: Gold Catalysis and Synthesis
Títol: Gold catalysis: Total Synthesis of the Englerins and an Approach Towards Shisanwilsonene A
Matèria: 547 - Química orgànica 54 - Química

Paraules clau:

547 - Química orgànica
54 - Química
Documents:

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