Dietary proanthocyanidins: their effectiveness in dyslipidemic nutritional models and the role of liver and intestine in their hypotriglyceridemic action

Identificador:  TDX:468

Handle: https://hdl.handle.net/20.500.11797/TDX468

Autors:  Quesada Vázquez, Helena

Resum:
Proanthocyanidins have been shown to exert advantageous actions on several metabolic disorders that are risk factors of cardiovascular diseases. Lipoprotein metabolism plays an important role in altered lipid states. Therefore, the aims of this Thesis were: To assess the contribution of the liver and the intestine in the hypolipidemic response triggered by proanthocyanidins and to evaluate the short-term effect of an oral intake of proanthocyanidins in dyslipidemic nutritional models. For these purposes, three experimental models have been used: Rats, mice and human Caco2 cells. The obtained results are: In a fat tolerance test, both chylomicrons and VLDL contribute to the hypotriglyceridemic action of proanthocyanidins but their influence depends on time. Moreover, proanthocyanidins repress TG secretion by the liver in vivo and by the intestine in vitro. Furthermore, ACSL manifests as their target gene in intestinal cells. Finally, proanthocyanidins correct dyslipidemia but not the weight gain induced by diet though these have a bimodal effect on energy retention in vivo.