Ni-Catalyzed Reductive Carboxylation Reactions with Carbon Dioxide

Identifier:  TDX:3352

Handle: https://hdl.handle.net/20.500.11797/TDX3352

Authors:  Börjesson Carazo, Marino Rolando

Abstract:
The primary greenhouse gas emitted due to the industrial development of our society is carbon dioxide. As a consequence, the recent years have witnessed the development of processes for the fixation of CO2 into organic molecules. Although the chemical utilization of CO2 will most likely not dramatically reduce its concentration in the atmosphere, its low cost and high availability could potentially help replace some of the established industrial processes that contribute to climate change. In particular, the carboxylic acid motif is present on a myriad of pharmaceuticals, agrochemicals or plastics, among others, making their synthesis an ideal target for CO2 chemical utilization. Unlike traditional carboxylations of highly polarized, sensitive organometallic reagents, reductive carboxylation reactions offer the possibility to employ simple electrophiles, representing a formidable alternative, conceptuality and practicality aside, to such nuclephilic entities. These doctoral studies have focused on the development and understanding of new, simple and practical reductive carboxylations reactions to produce carboxylic acids from inexpensive and abundant electrophiles by means of Ni-catalysis.