Silver-Catalyzed Cascade Conversions of CO2 into Heterocycles

Identifier:  TDX:4392

Handle: https://hdl.handle.net/20.500.11797/TDX4392

Authors:  Li, Xuetong

Abstract:
fCuantcailoyntiacl mcaesnctaed dee rsenascotsio dnes ucisnincog, CsOei2s ia ssi eat ere áatgoemnot sh.ave gained interest as they can lead to more complex structures resembling (parts of) pharma-relevant compounds. Cascade processes offer a way to combine several process steps into a one-pot procedure while having the opportunity to quickly assemble complex and functional scaffolds of interest in pharmaceutical discovery and development studies. Another observation in the area of CO2 catalysis is the privileged nature of Ag-catalysis to convert propargylic alcohols and CO2 into activated -alkylidene carbonates which have potential to undergo further reactions provided that suitable nucleophiles are present that can induce isomerization of the heterocyclic structure. In view of these features and notions, we envisioned that combining all these aspects would deliver a powerful approach to new types of heterocyclic compounds derived from CO2. The main objective of this doctoral thesis is the development of novel Ag-catalyzed cascade conversions of carbon dioxide into new types of heterocycles with a high level of functionality, substitution degree and further extending these procedures to larger ring carbonates and carbamates.