Towards highly efficent ligands for asymmetric hydrogenations: a covalent modular approach and investigations into bio-inspired supramolecular strategies

Identifier:  TDX:819

Handle: https://hdl.handle.net/20.500.11797/TDX819

Authors:  Fernández Pérez, Héctor

Abstract:
A library of enantiomerically pure P-OP ligands (phosphine-phoshinites and phosphine-phosphites) straightforwardly available in two synthetic steps from enantiopure Sharpless epoxy ethers is reported in the present PhD. Thesis. The 'lead' catalyst of the series has proven to have outstanding catalytic properties in the rhodium-catalysed asymmetric hydrogenation of a wide variety of functionalised alkenes. Their excellent performance and modular design makes them attractive for future applications.<br/>This PhD. Thesis also reports the development of a practical route to chiral diphosphine ligands with supramolecular motifs, with potential for allosteric modulation, which we prepared for future catalytic studies.