New Approaches to Catalyst Design and Immobilization

Identificador:  TDX:2512

Handle: https://hdl.handle.net/20.500.11797/TDX2512

Autores:  Sagamanova, Irina

Resumen:
estos casos la presencia del triazol que conecta la matriz polímérica y la unidad catalítica tiene un efecto negativo en el proceso, por lo que será necesario rediseñar el catalizador. Finalmente se han estudiado dos procesos de catálisis homogénea. Se presentan metodologías mejoradas para la formación de sulfóxidos de arilo a partir de cloruros de arilo catalizada por Pd y el desarrollo de un nuevo precatalizador para el acoplamiento de haluros para generar estirenos mediada por aniones sulfenato. This Thesis covers two main sections: (a) studies towards the synthesis of new immobilized organocatalysts and their application in a wide range of enantioselective transformations with the main goal of developing new continuous flow processes and (b) homogenous catalysis aimed at improving recently reported reactions of sulfenate anions (a Pdcatalyzed aryl sulfoxide formation, and the development of a second generation pre-catalyst for metal-free processes). The first part of this work is devoted to the application of polynorbornene as a robust support for the immobilization of homogeneous catalysts. To this aim, the aldol reaction has been selected. This material has shown high potential, comparable to the results obtained with a polystyrene matrix. It will be interesting to study alternative transformations for this type of materials, especially in photocatalytic applications and continuous flow processes. In the following chapters, new polymer-supported β-fluoroamines have been developed with two different approaches: copolymerization and click chemistry. Both the enamine and iminium ion activation modes have been considered to study asymmetric transformations.