Combination of advanced therapies and nanotechnology against cancer

Identifier:  TFG:1614

Handle: https://hdl.handle.net/20.500.11797/TFG1614

Authors:  Lalinde Ruiz, Marta

Abstract:
Cancer is one of the diseases with the highest mortality in the world. Specifically, in 2015, it was the second leading cause of mortality globally, producing 8,800,000 deaths. Due to the complexity of the tumors, the current treatments used are not entirely effective since they cause serious side effects. For this reason, our group decided to study new therapies against cancer that were more effective and less harmful. A multidisciplinary approach has been carried out based on the latest advances in cell therapy and nanomedicine, to try and advance and deepen into the field of new antineoplastic therapies. More specifically, the goal was to study various viral and / or non-viral formulations based on organic and inorganic nanomaterials for their potential application in the treatment of solid tumors. Given the context in which this research is carried out, it was considered to work in the absence of active viral particles, so that only inactivated capsids or plasmids that can not produce virions will be used. Keywords: Cancer, gene therapy, nanobiotechnology, transfection, viral vector, polymeric vector, oncolytic adenovirus.