Study of the integrated stress response pathway induced by fluorizoline in leukemia primary cells

Identifier:  TFG:5141

Handle: https://hdl.handle.net/20.500.11797/TFG5141

Authors:  Abadias Cortada, Esther

Abstract:
Fluorizoline is a synthetic compound that leads to apoptosis by selectively binding to mitochondrial prohibitin complex. Previous studies in cancer cells have shown that fluorizoline cause ER stress, leading to integrated stress response (ISR) activation and cell death. In this study, we have studied the ISR pathway induced by fluorizoline in chronic lymphocytic leukemia and acute myeloid leukemia primary cells. Cellular viability and protein expression have been analysed and the results demonstrated that fluorizoline treatment has induced apoptosis and eIF2α phosphorylation, suggesting that the ISR could be activated by fluorizoline. Therefore, fluorizoline could be a promising tool for cancer therapy.