Olfactomedin proteins and their potential involvement in nonalcoholic fatty liver disease

Identifier:  TFG:5697

Handle: https://hdl.handle.net/20.500.11797/TFG5697

Authors:  Barrientos Riosalido, Andrea

Abstract:
To provide new insights into the roles of Olfactomedin (OLFM)2 and OLFM4 related to nonalcoholic fatty liver disease NAFLD pathogenesis, in this study, we used RT-qPCR to analyse the mRNA expression of OLFM2 in liver biopsies and OLFM4 in jejunum samples, in a cohort of women with morbid obesity classified according to their hepatic histology. Our results showed that OLFM2 increased as NAFLD progresses and OLFM4 present positive correlations with interleukins and jejunal TLR9. In conclusion, OLFM2 in liver seems to play a relevant role in NAFLD progression, while OLFM4 in jejunum could be involved in gut dysbiosis related-inflammation events.