Extracellular vesicles as a brain mechanism of intercellular and interregional communication altered in schizophrenia

Identifier:  TFG:6108

Handle: https://hdl.handle.net/20.500.11797/TFG6108

Authors:  Onoiu, Alina Iuliana

Abstract:
The brain communication systems are disrupted in schizophrenia and the molecular basis for these alterations have not been yet established. In this work, we employed state-of-the-art neuroproteomics and systems biology approach to characterize the proteome composition(s) of brain extracellular vesicles (EVs), as key mediators of intercellular communication, between three specific brain regions: the prefrontal cortex, the caudate and the hippocampus. Post-mortem brain tissues of patients with schizophrenia were profiled (n=30). The results revealed depictive proteome regulation changes in the hippocampus. Moreover, some of the proteins identified were revealed as associated to a disrupted EVs-mediated interregional brain communication system in psychotic brains.