TDP-43 co-chaperones as potential inducers of neurodegeneration in ALS

Identifier:  TFG:7001

Handle: https://hdl.handle.net/20.500.11797/TFG7001

Authors:  Rahmouni Alami Afazaz, Sahar

Abstract:
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects motor neurons, producing muscle fiber atrophy. The misfolding of certain proteins, such as TDP-43, and the accumulation of these in the form of inclusions is a differential characteristic of this disease. Recently, the relevance of the co-chaperones of the HSP40 family has been described in TDP-43 proteinopathies. In this work, a study has been carried out of the protein expression levels of DNAJB1 and DNAJA2 in ALS patients versus control subjects, by means of simultaneous double immunofluorescence in post-mortem neural tissue.