Grape-seed proanthocyanidins and circadian disruption: a chrononutritional approach to liver lipid metabolism in rats

Identifier:  TFG:9016

Handle: https://hdl.handle.net/20.500.11797/TFG9016

Authors:  Urra López de Heredia, Nahia

Abstract:
Circadian disruption is frequently linked to metabolic disorders, particularly affecting hepatic lipid metabolism. This study analyses the effects of grape-seed proanthocyanidin-rich extract (GSPE, 25 mg/kg/day) in Wistar rats exposed to either a standard 24-h light–dark cycle or a shortened 22-h cycle. Hepatic triglyceride levels and lipid-related proteins were analysed across four Zeitgeber times. No significant triglyceride changes were found, although total ACC expression increased in the disrupted + GSPE group. Several proteins showed diurnal variation, confirming hepatic circadian resilience. These findings highlight GSPE’s limited effects under healthy conditions and the need for challenge models to assess its chrononutritional potential.